ISK1L_CHICK
ID ISK1L_CHICK Reviewed; 55 AA.
AC P85000;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Trypsin inhibitor ClTI-1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC TISSUE=Liver;
RA Kubiak A., Polanowski A.;
RL Submitted (SEP-2006) to UniProtKB.
CC -!- FUNCTION: Inhibits trypsin and plasmin. {ECO:0000269|Ref.1}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- MASS SPECTROMETRY: Mass=6025; Mass_error=2; Method=MALDI;
CC Evidence={ECO:0000269|Ref.1};
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DR AlphaFoldDB; P85000; -.
DR SMR; P85000; -.
DR STRING; 9031.ENSGALP00000018601; -.
DR MEROPS; I01.047; -.
DR PaxDb; P85000; -.
DR VEuPathDB; HostDB:geneid_770729; -.
DR eggNOG; KOG3649; Eukaryota.
DR HOGENOM; CLU_169765_6_1_1; -.
DR PhylomeDB; P85000; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:AgBase.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR001239; Prot_inh_Kazal-m.
DR Pfam; PF00050; Kazal_1; 1.
DR PRINTS; PR00290; KAZALINHBTR.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR PROSITE; PS00282; KAZAL_1; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Protease inhibitor;
KW Reference proteome; Secreted; Serine protease inhibitor.
FT CHAIN 1..55
FT /note="Trypsin inhibitor ClTI-1"
FT /id="PRO_0000257989"
FT DOMAIN 1..55
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT SITE 17..18
FT /note="Reactive bond"
FT /evidence="ECO:0000250|UniProtKB:P20155,
FT ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 6..37
FT /evidence="ECO:0000250|UniProtKB:P00995,
FT ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 15..34
FT /evidence="ECO:0000250|UniProtKB:P00995,
FT ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 23..55
FT /evidence="ECO:0000250|UniProtKB:P00995,
FT ECO:0000255|PROSITE-ProRule:PRU00798"
SQ SEQUENCE 55 AA; 6033 MW; B41E2DB70B00F454 CRC64;
SIPPACDKYS RLPGCPRDYS PVCGTDGKTY PNECVLCLSN SEENKNVQIY KSGMC
