ID   ISK1_ANGAN              Reviewed;          61 AA.
AC   P11706;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Probable pancreatic secretory proteinase inhibitor;
DE   AltName: Full=PSTI type;
OS   Anguilla anguilla (European freshwater eel) (Muraena anguilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC   Anguilla.
OX   NCBI_TaxID=7936;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=3371360; DOI=10.1111/j.1432-1033.1988.tb14075.x;
RA   Conlon J.M., Thim L.;
RT   "A peptide from the eel pancreas with structural similarity to human
RT   pancreatic secretory trypsin inhibitor.";
RL   Eur. J. Biochem. 174:149-153(1988).
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   PIR; S00630; TIEEH.
DR   AlphaFoldDB; P11706; -.
DR   SMR; P11706; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   InterPro; IPR001239; Prot_inh_Kazal-m.
DR   Pfam; PF00050; Kazal_1; 1.
DR   PRINTS; PR00290; KAZALINHBTR.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF100895; SSF100895; 1.
DR   PROSITE; PS00282; KAZAL_1; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor; Secreted;
KW   Serine protease inhibitor.
FT   CHAIN           1..61
FT                   /note="Probable pancreatic secretory proteinase inhibitor"
FT                   /id="PRO_0000073030"
FT   DOMAIN          6..61
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   SITE            23..24
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        12..43
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        21..40
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        29..61
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
SQ   SEQUENCE   61 AA;  6808 MW;  4E80965329C57FFC CRC64;
     EEKSGLYRKP SCGEMSAMHA CPMNFAPVCG TDGNTYPNEC SLCFQRQNTK TDILITKDDR
     C