ID   ISK1_STRCA              Reviewed;          69 AA.
AC   Q9PSM2;
DT   04-MAY-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Pancreatic secretory trypsin inhibitor;
DE   AltName: Full=Serine protease inhibitor Kazal-type 1;
GN   Name=SPINK1; Synonyms=PSTI;
OS   Struthio camelus (Common ostrich).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC   Struthio.
OX   NCBI_TaxID=8801;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=8872536; DOI=10.1111/j.1399-3011.1996.tb00829.x;
RA   Zhao M., Naude R.J., Muramoto K., Oelofsen W.;
RT   "Purification and characterization of ostrich pancreatic secretory trypsin
RT   inhibitor.";
RL   Int. J. Pept. Protein Res. 48:174-181(1996).
CC   -!- FUNCTION: This is a trypsin inhibitor, its physiological function is to
CC       prevent the trypsin-catalyzed premature activation of zymogens within
CC       the pancreas.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; Q9PSM2; -.
DR   SMR; Q9PSM2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   Pfam; PF00050; Kazal_1; 1.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF100895; SSF100895; 1.
DR   PROSITE; PS00282; KAZAL_1; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor; Secreted;
KW   Serine protease inhibitor.
FT   CHAIN           1..69
FT                   /note="Pancreatic secretory trypsin inhibitor"
FT                   /id="PRO_0000073029"
FT   DOMAIN          8..65
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   SITE            25..26
FT                   /note="Reactive bond"
FT   DISULFID        14..45
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        23..42
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        31..63
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
SQ   SEQUENCE   69 AA;  7656 MW;  CF8AE73BFC148870 CRC64;
     EPDSAADTGT EAACSNYDLK KGCAKIFDPV CGTDNILYSN ECLLCFQNLQ RKTNVRIKRR
     GTCQEPSPR