ISM_XENLA
ID ISM_XENLA Reviewed; 449 AA.
AC Q8QFV1;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Isthmin;
DE Flags: Precursor;
GN Name=ism1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=12128218; DOI=10.1016/s0925-4773(02)00123-5;
RA Pera E.M., Kim J.I., Martinez S.L., Brechner M., Li S.-Y., Wessely O.,
RA De Robertis E.M.;
RT "Isthmin is a novel secreted protein expressed as part of the Fgf-8
RT synexpression group in the Xenopus midbrain-hindbrain organizer.";
RL Mech. Dev. 116:169-172(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as an angiogenesis inhibitor.
CC {ECO:0000250|UniProtKB:A2ATD1}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed at the 4-cell stage embryo. Expressed at
CC gastrula stage in the ventral blastopore lip and the anterior end of
CC the notochord. Expressed at early neurula stage throughout the
CC notochord, the posterior paraxial mesoderm, cranial neural crest,
CC anterior edge of the neural plate and at the prospective midbrain-
CC hindbrain boundary (MHB) or isthmus organizer. Expressed at late
CC neurula stage in the posterior neural fold. Expressed at early tailbud
CC stage at the MHB until tadpole stage. Expressed at tailbud stage in the
CC branchial arches, ear placode and ventral mesoderm.
CC {ECO:0000269|PubMed:12128218}.
CC -!- DOMAIN: The C-terminal AMOP domain plays an important role in the anti-
CC angiogenic function of ISM1. {ECO:0000250|UniProtKB:A2ATD1}.
CC -!- SIMILARITY: Belongs to the isthmin family. {ECO:0000305}.
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DR EMBL; AY091635; AAM13976.1; -; mRNA.
DR EMBL; BC160753; AAI60753.1; -; mRNA.
DR RefSeq; NP_001082228.1; NM_001088759.1.
DR AlphaFoldDB; Q8QFV1; -.
DR SMR; Q8QFV1; -.
DR PRIDE; Q8QFV1; -.
DR GeneID; 398306; -.
DR KEGG; xla:398306; -.
DR CTD; 398306; -.
DR Xenbase; XB-GENE-963588; ism1.L.
DR OMA; CYDDSMQ; -.
DR OrthoDB; 876510at2759; -.
DR Proteomes; UP000186698; Chromosome 5L.
DR Bgee; 398306; Expressed in blastula and 16 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.20.100.10; -; 1.
DR InterPro; IPR005533; AMOP_dom.
DR InterPro; IPR042413; ISM.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR10239:SF30; PTHR10239:SF30; 1.
DR Pfam; PF03782; AMOP; 1.
DR Pfam; PF00090; TSP_1; 1.
DR SMART; SM00723; AMOP; 1.
DR SMART; SM00209; TSP1; 1.
DR SUPFAM; SSF82895; SSF82895; 1.
DR PROSITE; PS50856; AMOP; 1.
DR PROSITE; PS50092; TSP1; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..449
FT /note="Isthmin"
FT /id="PRO_0000348260"
FT DOMAIN 203..247
FT /note="TSP type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DOMAIN 274..437
FT /note="AMOP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00347"
FT REGION 27..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 270
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 214..241
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 218..246
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 229..233
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
SQ SEQUENCE 449 AA; 50975 MW; C0606CC927568AB8 CRC64;
MLRLAAELLL LLGLLLLTLH ITVLRGSPDS SSNSSHSLIQ NEPSSDSFSF NPSDRQEYLD
EATRRAFPKH RLMTSGHTSL QRDGTGSFLL DLPNFPDLSK VDINGQNPNI QVTIEVVDGP
DSEPENEMQK ENMPSWPVPS PDWRSWWQRS ATLPRMNYGD QDYKYDSTTE DSNFLNPLGG
RNRQVPSHRT FDTKEQPEYD YVDGEGDWSS WSVCSVTCGS GNQKRTRTCG YACTATESRT
CDMPNCPGIE DTFRTAATEV SLLAGNEDFN ATKLFGVDTD SCERWMNCKS EFLKKYMHKV
ANDLPSCPCS YPTEVAYSTA EIYDRIKRKD FRWKDASGPK EKLEIYKPTA RYCIRSMLSL
ESTTLAAQHC CFDDSMQLIT RGKGAGTPNL ISVEFSAELH YKVDILPWIM CKGDWSRYNE
VRPPNNGQKC TENPSEDDYL KQFQEAREF