ID   ISN1_CANGA              Reviewed;         447 AA.
AC   Q6FLD4;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=IMP-specific 5'-nucleotidase 1;
DE            EC=3.1.3.99 {ECO:0000250|UniProtKB:Q99312};
GN   Name=ISN1; OrderedLocusNames=CAGL0L04268g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: IMP-specific 5'-nucleotidase involved in IMP (inositol
CC       monophosphate) degradation. {ECO:0000250|UniProtKB:Q99312}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + IMP = inosine + phosphate; Xref=Rhea:RHEA:27718,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:17596, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58053; EC=3.1.3.99;
CC         Evidence={ECO:0000250|UniProtKB:Q99312};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000250|UniProtKB:Q99312};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:Q99312}.
CC   -!- SIMILARITY: Belongs to the ISN1 family. {ECO:0000305}.
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DR   EMBL; CR380958; CAG61930.1; -; Genomic_DNA.
DR   RefSeq; XP_448960.1; XM_448960.1.
DR   AlphaFoldDB; Q6FLD4; -.
DR   SMR; Q6FLD4; -.
DR   STRING; 5478.XP_448960.1; -.
DR   EnsemblFungi; CAG61930; CAG61930; CAGL0L04268g.
DR   GeneID; 2890774; -.
DR   KEGG; cgr:CAGL0L04268g; -.
DR   CGD; CAL0135600; CAGL0L04268g.
DR   VEuPathDB; FungiDB:CAGL0L04268g; -.
DR   eggNOG; ENOG502QR24; Eukaryota.
DR   HOGENOM; CLU_031816_1_0_1; -.
DR   InParanoid; Q6FLD4; -.
DR   OMA; FKARLAC; -.
DR   Proteomes; UP000002428; Chromosome L.
DR   GO; GO:0050483; F:IMP 5'-nucleotidase activity; IEA:EnsemblFungi.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0006190; P:inosine salvage; IEA:EnsemblFungi.
DR   GO; GO:0071590; P:nicotinamide riboside biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:0071592; P:nicotinic acid riboside biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR009453; ISN1.
DR   PANTHER; PTHR28213; PTHR28213; 1.
DR   Pfam; PF06437; ISN1; 1.
DR   PIRSF; PIRSF028836; ISN1; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium; Nucleotide metabolism; Reference proteome.
FT   CHAIN           1..447
FT                   /note="IMP-specific 5'-nucleotidase 1"
FT                   /id="PRO_0000084249"
SQ   SEQUENCE   447 AA;  50888 MW;  1DB5F1526C43E896 CRC64;
     MSSRYRVEYH LKSHRKDGFI DWIKGLLAAP FVLHAVSHDG DDNDELATTQ RVRSQYAEIF
     KDIESLVSDK ILFDERNDQY RQYIESNDVE EVIPLGQPRL DLLVPTIGTF FTQLPLEKAF
     LWEDARKAIS SRRMVAPSFN DIRHILNTAQ VFHFIKQRKL KSKDQLRMCT FDGDVTLYED
     GGSIVNTNPV IPLLVKLLSE GVCIGIVTAA GYDEAKTYES RLNGLITALN GSDLPYAKKR
     NLCVMGGESN YLFRYYEDGE SFGFEAIDKE GWLLPRMCTW SQDDLTQTLD FAEKTLYRLK
     KRLNLPEEAI IMRKARAVGI VPGHFKDPET GNMVKIQLDR EQLEEVVLTL QNSLEGFAPA
     QRIQYSCFDG GSDVWCDIGG KDLGVRALQH YYDPENPIKP SQTLHVGDQF APVGSANDFK
     ARLAGCTLWI SSPKETVEYL RRLIHDE