ISOC1_MOUSE
ID ISOC1_MOUSE Reviewed; 297 AA.
AC Q91V64; Q3U677;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Isochorismatase domain-containing protein 1;
GN Name=Isoc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=SWR/J; TISSUE=Embryonic fibroblast;
RX PubMed=12198563;
RA Yang J.S., Zheng X.M., Chen S.S.;
RT "Screening and identification of tumor related genes in early stages of
RT transformed NIH3T3 cells associated with overexpressed PTPalpha.";
RL Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:601-607(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-278, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- SIMILARITY: Belongs to the isochorismatase family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY035213; AAK64607.1; -; mRNA.
DR EMBL; AK134794; BAE22288.1; -; mRNA.
DR EMBL; AK152763; BAE31476.1; -; mRNA.
DR EMBL; AK153257; BAE31848.1; -; mRNA.
DR EMBL; BC016576; AAH16576.1; -; mRNA.
DR CCDS; CCDS29265.1; -.
DR RefSeq; NP_079754.2; NM_025478.3.
DR AlphaFoldDB; Q91V64; -.
DR SMR; Q91V64; -.
DR BioGRID; 211371; 12.
DR STRING; 10090.ENSMUSP00000025503; -.
DR iPTMnet; Q91V64; -.
DR PhosphoSitePlus; Q91V64; -.
DR SwissPalm; Q91V64; -.
DR EPD; Q91V64; -.
DR jPOST; Q91V64; -.
DR MaxQB; Q91V64; -.
DR PaxDb; Q91V64; -.
DR PeptideAtlas; Q91V64; -.
DR PRIDE; Q91V64; -.
DR ProteomicsDB; 269408; -.
DR Antibodypedia; 63783; 63 antibodies from 17 providers.
DR DNASU; 66307; -.
DR Ensembl; ENSMUST00000025503; ENSMUSP00000025503; ENSMUSG00000024601.
DR GeneID; 66307; -.
DR KEGG; mmu:66307; -.
DR UCSC; uc008ezq.1; mouse.
DR CTD; 51015; -.
DR MGI; MGI:1913557; Isoc1.
DR VEuPathDB; HostDB:ENSMUSG00000024601; -.
DR eggNOG; KOG4044; Eukaryota.
DR GeneTree; ENSGT00390000006753; -.
DR HOGENOM; CLU_047255_0_0_1; -.
DR InParanoid; Q91V64; -.
DR OMA; LVNERCK; -.
DR OrthoDB; 1100720at2759; -.
DR PhylomeDB; Q91V64; -.
DR TreeFam; TF313459; -.
DR BioGRID-ORCS; 66307; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Isoc1; mouse.
DR PRO; PR:Q91V64; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q91V64; protein.
DR Bgee; ENSMUSG00000024601; Expressed in facial nucleus and 264 other tissues.
DR ExpressionAtlas; Q91V64; baseline and differential.
DR Genevisible; Q91V64; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005777; C:peroxisome; ISS:HGNC-UCL.
DR Gene3D; 3.40.50.850; -; 1.
DR InterPro; IPR000868; Isochorismatase-like.
DR InterPro; IPR036380; Isochorismatase-like_sf.
DR Pfam; PF00857; Isochorismatase; 1.
DR SUPFAM; SSF52499; SSF52499; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..297
FT /note="Isochorismatase domain-containing protein 1"
FT /id="PRO_0000268665"
FT MOD_RES 159
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q6I7R3"
FT MOD_RES 278
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT CONFLICT 149
FT /note="L -> F (in Ref. 2; BAE31476/BAE31848)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 297 AA; 32033 MW; 95F09A49D2EE29C2 CRC64;
MAAAEPSVAA LAGGGVGAGA PSGGVPVLFC FSVFARPASV PHGAGYDVLI QKFLSLYGDQ
LDMHRKFVVQ LFAEEWGQYV DLPKGFAVSE RCKLRLVPLQ IQLTTLGNLT PPSTVFFCCD
MQERFRPAIK YFGDIISVGQ RLLQGARILG IPVIITEQYP KGLGSTVQEI DLTGVKLVLP
KTKFSMVLPE VEAALAEIPG VRSVVLFGVE THVCIQQTAL ELVGRGIEVH IVADATSSRS
MMDRMFALER LARTGIIVTT SEAVLLQLVA DKDHPKFKEI QNLIKASAPE SGLLSKV
