ID   ISOC1_RAT               Reviewed;         297 AA.
AC   Q6I7R3;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Isochorismatase domain-containing protein 1;
DE   AltName: Full=Down-regulated in nephrectomized rat kidney protein 1;
DE            Short=DR-NR1;
GN   Name=Isoc1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   STRAIN=Wistar; TISSUE=Kidney;
RX   PubMed=15200410; DOI=10.1111/j.1523-1755.2004.00704.x;
RA   Horiba N., Masuda S., Takeuchi A., Saito H., Okuda M., Inui K.;
RT   "Gene expression variance based on random sequencing in rat remnant
RT   kidney.";
RL   Kidney Int. 66:29-45(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-159, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- TISSUE SPECIFICITY: Specifically expressed in spleen and kidney.
CC       {ECO:0000269|PubMed:15200410}.
CC   -!- INDUCTION: Down-regulated after nephrectomy.
CC       {ECO:0000269|PubMed:15200410}.
CC   -!- SIMILARITY: Belongs to the isochorismatase family. {ECO:0000305}.
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DR   EMBL; AB108669; BAD23894.1; -; mRNA.
DR   RefSeq; NP_001014264.1; NM_001014242.1.
DR   AlphaFoldDB; Q6I7R3; -.
DR   SMR; Q6I7R3; -.
DR   STRING; 10116.ENSRNOP00000026706; -.
DR   iPTMnet; Q6I7R3; -.
DR   PhosphoSitePlus; Q6I7R3; -.
DR   jPOST; Q6I7R3; -.
DR   PaxDb; Q6I7R3; -.
DR   PRIDE; Q6I7R3; -.
DR   GeneID; 364879; -.
DR   KEGG; rno:364879; -.
DR   UCSC; RGD:1307632; rat.
DR   CTD; 51015; -.
DR   RGD; 1307632; Isoc1.
DR   eggNOG; KOG4044; Eukaryota.
DR   InParanoid; Q6I7R3; -.
DR   OrthoDB; 1100720at2759; -.
DR   PhylomeDB; Q6I7R3; -.
DR   PRO; PR:Q6I7R3; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005777; C:peroxisome; IDA:HGNC-UCL.
DR   Gene3D; 3.40.50.850; -; 1.
DR   InterPro; IPR000868; Isochorismatase-like.
DR   InterPro; IPR036380; Isochorismatase-like_sf.
DR   Pfam; PF00857; Isochorismatase; 1.
DR   SUPFAM; SSF52499; SSF52499; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..297
FT                   /note="Isochorismatase domain-containing protein 1"
FT                   /id="PRO_0000268666"
FT   MOD_RES         159
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         278
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91V64"
SQ   SEQUENCE   297 AA;  32002 MW;  E86EE3BF0EA24D04 CRC64;
     MAAAEPSVAA LAGGGVGAGA PSGGVPVLFC FSVFARPASV PHGAGYDVLI QKFLSLYGDQ
     VDMHRKFVVQ LFAEEWGQYV DLPKGFAVSE RCKLRLVPLQ IQLTTLGNLT PPSTVFFCCD
     MQERFRPAIK YFGDIISVGQ RLLQGARILG IPVIITEQYP KGLGSTVQEI DLTGVKLVLP
     KTKFSMVLPE VEAALAEIPG VRSVVLFGVE THVCIQQTAL ELVGRGIEVH IVADATSSRS
     MMDRMFALER LARTGIIVTT SEAVPLQLVA DKDHPKFKEI QNLIKASAPE SGLLSKV