ID   ISOC2_PONAB             Reviewed;         205 AA.
AC   Q5RC03;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Isochorismatase domain-containing protein 2;
GN   Name=ISOC2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Interacts with CDKN2A. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Localizes to the nucleus in the presence of CDKN2A. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the isochorismatase family. {ECO:0000305}.
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DR   EMBL; CR858479; CAH90707.1; -; mRNA.
DR   RefSeq; NP_001127324.1; NM_001133852.1.
DR   AlphaFoldDB; Q5RC03; -.
DR   SMR; Q5RC03; -.
DR   STRING; 9601.ENSPPYP00000011680; -.
DR   GeneID; 100174385; -.
DR   KEGG; pon:100174385; -.
DR   CTD; 79763; -.
DR   eggNOG; KOG4044; Eukaryota.
DR   InParanoid; Q5RC03; -.
DR   OrthoDB; 1100720at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.850; -; 1.
DR   InterPro; IPR040318; ISOC2.
DR   InterPro; IPR000868; Isochorismatase-like.
DR   InterPro; IPR036380; Isochorismatase-like_sf.
DR   PANTHER; PTHR14119:SF4; PTHR14119:SF4; 1.
DR   Pfam; PF00857; Isochorismatase; 1.
DR   SUPFAM; SSF52499; SSF52499; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..205
FT                   /note="Isochorismatase domain-containing protein 2"
FT                   /id="PRO_0000268674"
FT   MOD_RES         7
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96AB3"
FT   MOD_RES         202
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96AB3"
SQ   SEQUENCE   205 AA;  22321 MW;  4ACA5A25446E696E CRC64;
     MAAARPSLGR VLPGSSILFL CDMQEKFRHN IAYFPQIVSV AARMLRVARL LEVPVMLTEQ
     YPQGLGPTVP ELGAEGLRPL AKTCFSMVPA LRQELDSRPQ LRSVLLCGIE AQACILNTTL
     DLLDQGLQVH VVVDACSSRS QVDRLVALAR MRQSGAFLST SEGLILQLVG DAAHPQFKEI
     QKLIKEPAPD SGLLGLFQGQ NSLLH