ID   ISOC2_RAT               Reviewed;         210 AA.
AC   Q5U3Z3;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Isochorismatase domain-containing protein 2;
GN   Name=Isoc2; Synonyms=Isoc2b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Interacts with CDKN2A. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Localizes to the nucleus in the presence of CDKN2A. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the isochorismatase family. {ECO:0000305}.
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DR   EMBL; BC085336; AAH85336.1; -; mRNA.
DR   RefSeq; NP_001008368.1; NM_001008367.1.
DR   AlphaFoldDB; Q5U3Z3; -.
DR   SMR; Q5U3Z3; -.
DR   STRING; 10116.ENSRNOP00000022621; -.
DR   iPTMnet; Q5U3Z3; -.
DR   PhosphoSitePlus; Q5U3Z3; -.
DR   PaxDb; Q5U3Z3; -.
DR   PRIDE; Q5U3Z3; -.
DR   GeneID; 361501; -.
DR   KEGG; rno:361501; -.
DR   UCSC; RGD:1309062; rat.
DR   CTD; 67441; -.
DR   RGD; 1309062; Isoc2b.
DR   VEuPathDB; HostDB:ENSRNOG00000016829; -.
DR   eggNOG; KOG4044; Eukaryota.
DR   HOGENOM; CLU_066901_0_1_1; -.
DR   InParanoid; Q5U3Z3; -.
DR   OMA; IMTSAPD; -.
DR   OrthoDB; 1100720at2759; -.
DR   PhylomeDB; Q5U3Z3; -.
DR   TreeFam; TF313459; -.
DR   PRO; PR:Q5U3Z3; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000016829; Expressed in heart and 19 other tissues.
DR   Genevisible; Q5U3Z3; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.850; -; 1.
DR   InterPro; IPR000868; Isochorismatase-like.
DR   InterPro; IPR036380; Isochorismatase-like_sf.
DR   Pfam; PF00857; Isochorismatase; 1.
DR   SUPFAM; SSF52499; SSF52499; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..210
FT                   /note="Isochorismatase domain-containing protein 2"
FT                   /id="PRO_0000268675"
FT   MOD_RES         7
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96AB3"
SQ   SEQUENCE   210 AA;  23157 MW;  E41B89599CA043A9 CRC64;
     MAAARASLGR IFPESSILFL CDMQEKLRDR VLYFPQIVSM AARMLKVARI LDVPVLLTEH
     YPQGLGPTVP ELGAQGVRTM SKTSFSMVPP LQQELDKLPQ LKSVLLCGIE TQVCILNTAL
     DLLDRGLQVH VAVDACSSQS EMNRLVALAR MQHSGVFLST SEALTLQLIK DAAHPQFKEI
     QKILKEPVPE IGLLGFFQGM NNPLLPNSRP