ISP4_SCHPO
ID ISP4_SCHPO Reviewed; 785 AA.
AC P40900; P78943; Q9HGP2; Q9UU01;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 14-AUG-2001, sequence version 2.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=Sexual differentiation process protein isp4;
GN Name=isp4; ORFNames=SPBC29B5.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7954893; DOI=10.1007/bf00326301;
RA Sato S., Suzuki H., Widyastuti U., Hotta Y., Tabata S.;
RT "Identification and characterization of genes induced during sexual
RT differentiation in Schizosaccharomyces pombe.";
RL Curr. Genet. 26:31-37(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RA Kohnosu A., Niwa O., Yano M., Saitoh S., Katayama T., Nagao K.,
RA Yanagida M.;
RT "S.pombe chromosome II cosmid 1228 sequence.";
RL Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-143, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}; Multi-pass
CC membrane protein {ECO:0000269|PubMed:10759889,
CC ECO:0000269|PubMed:16823372}.
CC -!- DEVELOPMENTAL STAGE: Transcribed specifically during sexual
CC development.
CC -!- SIMILARITY: Belongs to the oligopeptide OPT transporter family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA12193.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAA12193.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
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DR EMBL; D14061; BAA03147.1; -; mRNA.
DR EMBL; D83992; BAA12193.1; ALT_FRAME; Genomic_DNA.
DR EMBL; CU329671; CAC05511.1; -; Genomic_DNA.
DR EMBL; AB027895; BAA87199.1; -; Genomic_DNA.
DR PIR; S45495; S45495.
DR RefSeq; NP_595653.1; NM_001021547.2.
DR AlphaFoldDB; P40900; -.
DR BioGRID; 276893; 11.
DR STRING; 4896.SPBC29B5.02c.1; -.
DR TCDB; 2.A.67.1.2; the oligopeptide transporter (opt) family.
DR iPTMnet; P40900; -.
DR MaxQB; P40900; -.
DR PaxDb; P40900; -.
DR EnsemblFungi; SPBC29B5.02c.1; SPBC29B5.02c.1:pep; SPBC29B5.02c.
DR GeneID; 2540364; -.
DR KEGG; spo:SPBC29B5.02c; -.
DR PomBase; SPBC29B5.02c; isp4.
DR VEuPathDB; FungiDB:SPBC29B5.02c; -.
DR eggNOG; KOG2262; Eukaryota.
DR HOGENOM; CLU_004965_1_1_1; -.
DR InParanoid; P40900; -.
DR OMA; NYDEGGH; -.
DR PhylomeDB; P40900; -.
DR PRO; PR:P40900; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IDA:PomBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:PomBase.
DR GO; GO:0035673; F:oligopeptide transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1901584; F:tetrapeptide transmembrane transporter activity; IMP:PomBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:1901583; P:tetrapeptide import across plasma membrane; IMP:PomBase.
DR InterPro; IPR004648; Oligpept_transpt.
DR InterPro; IPR004813; OPT.
DR PANTHER; PTHR22601; PTHR22601; 1.
DR Pfam; PF03169; OPT; 1.
DR TIGRFAMs; TIGR00727; ISP4_OPT; 1.
DR TIGRFAMs; TIGR00728; OPT_sfam; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; Peptide transport; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..785
FT /note="Sexual differentiation process protein isp4"
FT /id="PRO_0000213787"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 490..510
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 512..532
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 537..557
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 572..592
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 611..631
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 642..662
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 683..703
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 732..752
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 725
FT /note="Missing (in Ref. 1; BAA03147)"
FT /evidence="ECO:0000305"
FT CONFLICT 777..785
FT /note="GEFFGPAEW -> R (in Ref. 1; BAA03147)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 785 AA; 89192 MW; 3F19825269BFA75D CRC64;
MIGSINESPI EEHMNDSPST KEKADSVDIS DYIVSHSDDS LSKDIKKDTK SFLDVEHGEI
STVDEFEEDS PYPEVRAAVP PTDDPSMPCN TIRMWTIGLI YSTVGAAVNM FFSLRNPTVT
LSVLISELLA YPALQIWDLI FPDREFRIGR LKFNFKPGPF NVKEHALIVV MSSVSFGNAY
STDIILAQRV HYKQRFGFGY EICLTLATQL IGYGLAGLSR RLLVRPASML WPVNLVQCTL
IKTLHRKDLR NAVANGWRIS PFRFFLYVFI ASFIWNWFPS YIFQALSLFA WVTWIRPNSP
TVNQIFGEST GISILPMTFD WNQISAYILS PLMAPADALM NILLGVILFF WIVTPALNFT
NTWYGDYLPI SSSGIIDHFG NSYNVTRILT KDATFDLDAY QNYSPIFMST TYALAFGLSF
ASITSVIFHV ILYHGKEIYD RLRDPPAPDI HEKLMKAYDE VPFYWYLSVF LAFFGMMMGT
IYGWKTETPW WVIIVGVIFS AVWFIPIGIV QAITNIQLGL NVFTEFIVGY MYPGRPLAMM
IFKTVGYITM TQGLAFAADL KFGHYMKLPP RIMFYTQMIA TIWSCFVQIG VLDWALGNID
NVCQADQPDN YTCPNATVFF NSSVIWGVIG PKRMFSGKNT YTGLQYFWLA GVLGTILFWA
LWKKWPQKWW GQLNGPLIFG GTGYIPPATP VNYLAWSGIG LFFNYYLKKI FADWWQKYNF
TLSAALDTGT QLSVIILFFC LQLPMVNFPD WWGNDGAFNT LDATGAAVRK LVNESAGEFF
GPAEW
