ISP5_SCHPO
ID ISP5_SCHPO Reviewed; 580 AA.
AC P40901; Q9US32;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 14-AUG-2001, sequence version 2.
DT 25-MAY-2022, entry version 148.
DE RecName: Full=Sexual differentiation process putative amino-acid permease isp5;
GN Name=isp5; ORFNames=SPAC1039.09;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7954893; DOI=10.1007/bf00326301;
RA Sato S., Suzuki H., Widyastuti U., Hotta Y., Tabata S.;
RT "Identification and characterization of genes induced during sexual
RT differentiation in Schizosaccharomyces pombe.";
RL Curr. Genet. 26:31-37(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Transcribed specifically during sexual
CC development.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA03148.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; D14062; BAA03148.1; ALT_FRAME; mRNA.
DR EMBL; CU329670; CAB63545.1; -; Genomic_DNA.
DR PIR; S45492; S45492.
DR PIR; T50059; T50059.
DR RefSeq; NP_595000.1; NM_001020431.2.
DR AlphaFoldDB; P40901; -.
DR SMR; P40901; -.
DR BioGRID; 279464; 1.
DR STRING; 4896.SPAC1039.09.1; -.
DR MaxQB; P40901; -.
DR PaxDb; P40901; -.
DR EnsemblFungi; SPAC1039.09.1; SPAC1039.09.1:pep; SPAC1039.09.
DR GeneID; 2543028; -.
DR KEGG; spo:SPAC1039.09; -.
DR PomBase; SPAC1039.09; isp5.
DR VEuPathDB; FungiDB:SPAC1039.09; -.
DR eggNOG; KOG1286; Eukaryota.
DR HOGENOM; CLU_007946_12_0_1; -.
DR InParanoid; P40901; -.
DR OMA; CLSVHIM; -.
DR PhylomeDB; P40901; -.
DR PRO; PR:P40901; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; ISM:PomBase.
DR GO; GO:0003333; P:amino acid transmembrane transport; ISM:PomBase.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR004840; Amoino_acid_permease_CS.
DR Pfam; PF00324; AA_permease; 1.
DR PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..580
FT /note="Sexual differentiation process putative amino-acid
FT permease isp5"
FT /id="PRO_0000054167"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 515..535
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 63850 MW; A4927B9860BF7CD0 CRC64;
MNNYGVSSIG TSLTPSPTGS IDEYTSKEVK HPEDVKVDAS YEKEEVGYGE LEVVPERGNL
FQRWYRSFLP PEDGKPQKLK RTLTARHIQM IGIGGAIGTG VWVGSKNTLR EGGAASVLIC
YSLVGSMVLM TVYSLGELAV AFPINGSFHT YGTRFIHPSW GFTLGWNYLA SFLATYPLEL
ITASICLQFW ININSGIWIT VFIALLCFVN MFGVRGYGEV EFFVSSLKVM AMVGFIICGI
VIDCGGVRTD HRGYIGATIF RKNAFIHGFH GFCSVFSTAA FSYAGTEYIG IAASETKNPA
KAFPKAVKQV FIRVSLFYIL ALFVVSLLIS GRDERLTTLS ATAASPFILA LMDAKIRGLP
HVLNAVILIS VLTAANGITY TGSRTLHSMA EQGHAPKWFK YVDREGRPLL AMAFVLCFGA
LGYICESAQS DTVFDWLLSI SNLATLFVWL SINVSYIIYR LAFKKQGKSY DEVGYHSPFG
IYGACYGAFI IILVFITEFY VSIFPIGASP DAGAFFQSYL CFPVVVIVFI AHALITRQKF
RKLSEIDLDT GFSKYDRLEE SDKGPMTAKS LAKSVLSFCV
