ID   ISP7_SCHPO              Reviewed;         397 AA.
AC   P40902;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Sexual differentiation process protein isp7;
GN   Name=isp7; ORFNames=SPAC25B8.13c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7954893; DOI=10.1007/bf00326301;
RA   Sato S., Suzuki H., Widyastuti U., Hotta Y., Tabata S.;
RT   "Identification and characterization of genes induced during sexual
RT   differentiation in Schizosaccharomyces pombe.";
RL   Curr. Genet. 26:31-37(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- DEVELOPMENTAL STAGE: Transcribed specifically during sexual
CC       development.
CC   -!- SIMILARITY: Belongs to the iron/ascorbate-dependent oxidoreductase
CC       family. {ECO:0000305}.
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DR   EMBL; D14064; BAA03150.1; -; mRNA.
DR   EMBL; CU329670; CAB61779.1; -; Genomic_DNA.
DR   PIR; S45496; S45496.
DR   RefSeq; NP_594473.1; NM_001019902.2.
DR   AlphaFoldDB; P40902; -.
DR   SMR; P40902; -.
DR   BioGRID; 279178; 8.
DR   STRING; 4896.SPAC25B8.13c.1; -.
DR   iPTMnet; P40902; -.
DR   MaxQB; P40902; -.
DR   PaxDb; P40902; -.
DR   PRIDE; P40902; -.
DR   EnsemblFungi; SPAC25B8.13c.1; SPAC25B8.13c.1:pep; SPAC25B8.13c.
DR   GeneID; 2542728; -.
DR   KEGG; spo:SPAC25B8.13c; -.
DR   PomBase; SPAC25B8.13c; isp7.
DR   VEuPathDB; FungiDB:SPAC25B8.13c; -.
DR   eggNOG; KOG0143; Eukaryota.
DR   HOGENOM; CLU_010119_6_3_1; -.
DR   InParanoid; P40902; -.
DR   OMA; KYAMAPG; -.
DR   PhylomeDB; P40902; -.
DR   PRO; PR:P40902; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0051213; F:dioxygenase activity; IBA:GO_Central.
DR   GO; GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
DR   GO; GO:1905736; P:negative regulation of L-proline import across plasma membrane; IMP:PomBase.
DR   GO; GO:1905589; P:positive regulation of L-arginine import across plasma membrane; IMP:PomBase.
DR   Gene3D; 2.60.120.330; -; 1.
DR   InterPro; IPR026992; DIOX_N.
DR   InterPro; IPR044861; IPNS-like_FE2OG_OXY.
DR   InterPro; IPR027443; IPNS-like_sf.
DR   InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR   Pfam; PF03171; 2OG-FeII_Oxy; 1.
DR   Pfam; PF14226; DIOX_N; 1.
DR   PROSITE; PS51471; FE2OG_OXY; 1.
PE   2: Evidence at transcript level;
KW   Iron; Oxidoreductase; Reference proteome; Vitamin C.
FT   CHAIN           1..397
FT                   /note="Sexual differentiation process protein isp7"
FT                   /id="PRO_0000067298"
FT   DOMAIN          255..353
FT                   /note="Fe2OG dioxygenase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
SQ   SEQUENCE   397 AA;  43811 MW;  5076C03C39B10A2B CRC64;
     MLSQLIERST QYVREASLEE QNRIMPLIDF GPYVNQEPGA HERIIQQLRA ACESTGFFQI
     VNSPISPDVV KNAFRASKQF FELPFDEKLT LSKDMFSNRG YELMEDFVLE GEEDSSSPLE
     ISGIDFEAGS YPGEAPLPPS SIGYVLPPSS LANGEGSSMF DADMTTSNAV AHGDESISNE
     FRESFYFGND NLSKDRLLRP FQGPNKWPST AGSSFRKALV KYHDQMLAFA NHVMSLLAES
     LELSPDAFDE FCSDPTTSIR LLRYPSSPNR LGVQEHTDAD ALTLMSQDNV KGLEILDPVS
     NCFLSVSPAP GALIANLGDI MAILTNNRYK SSMHRVCNNS GSDRYTIPFF LQGNIDYVVA
     PLPGLGPSTA EPIAVEDLLR DHFQNSYTSH TTSLEVA