APT_CAEEL
ID APT_CAEEL Reviewed; 185 AA.
AC P91455;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Adenine phosphoribosyltransferase;
DE Short=APRT;
DE EC=2.4.2.7;
GN ORFNames=T19B4.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Bristol N2;
RA Kohara Y., Shin-i T., Suzuki Y., Sugano S., Potdevin M., Thierry-Mieg Y.,
RA Thierry-Mieg D., Thierry-Mieg J.;
RT "The Caenorhabditis elegans transcriptome project, a complementary view of
RT the genome.";
RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes a salvage reaction resulting in the formation of
CC AMP, that is energically less costly than de novo synthesis.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate +
CC adenine; Xref=Rhea:RHEA:16609, ChEBI:CHEBI:16708, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58017, ChEBI:CHEBI:456215; EC=2.4.2.7;
CC -!- PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP
CC from adenine: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC family. {ECO:0000305}.
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DR EMBL; FO080338; CCD62975.1; -; Genomic_DNA.
DR EMBL; AF303266; AAG50224.1; -; mRNA.
DR PIR; T25891; T25891.
DR RefSeq; NP_491663.1; NM_059262.7.
DR AlphaFoldDB; P91455; -.
DR SMR; P91455; -.
DR BioGRID; 37689; 23.
DR STRING; 6239.T19B4.3; -.
DR EPD; P91455; -.
DR PaxDb; P91455; -.
DR PeptideAtlas; P91455; -.
DR EnsemblMetazoa; T19B4.3.1; T19B4.3.1; WBGene00020557.
DR GeneID; 172232; -.
DR KEGG; cel:CELE_T19B4.3; -.
DR UCSC; T19B4.3.1; c. elegans.
DR CTD; 172232; -.
DR WormBase; T19B4.3; CE13740; WBGene00020557; -.
DR eggNOG; KOG1712; Eukaryota.
DR GeneTree; ENSGT00390000017259; -.
DR HOGENOM; CLU_063339_3_2_1; -.
DR InParanoid; P91455; -.
DR OMA; KPGIVFR; -.
DR OrthoDB; 1291050at2759; -.
DR PhylomeDB; P91455; -.
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR Reactome; R-CEL-74217; Purine salvage.
DR UniPathway; UPA00588; UER00646.
DR PRO; PR:P91455; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00020557; Expressed in larva and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0002055; F:adenine binding; IBA:GO_Central.
DR GO; GO:0003999; F:adenine phosphoribosyltransferase activity; IBA:GO_Central.
DR GO; GO:0016208; F:AMP binding; IBA:GO_Central.
DR GO; GO:0006168; P:adenine salvage; IBA:GO_Central.
DR GO; GO:0044209; P:AMP salvage; IBA:GO_Central.
DR GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR HAMAP; MF_00004; Aden_phosphoribosyltr; 1.
DR InterPro; IPR005764; Ade_phspho_trans.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR Pfam; PF00156; Pribosyltran; 1.
DR SUPFAM; SSF53271; SSF53271; 1.
DR TIGRFAMs; TIGR01090; apt; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Glycosyltransferase; Purine salvage; Reference proteome;
KW Transferase.
FT CHAIN 1..185
FT /note="Adenine phosphoribosyltransferase"
FT /id="PRO_0000149511"
SQ SEQUENCE 185 AA; 20210 MW; 91A984C4F770F268 CRC64;
MTLPRFDQIR PKIEQHIREV KDFPKKGINF RDIMPLFTNP QLVNELCVVI ADHVRHTVGH
VDSVAGLEAR GFLFGPQVAI QLGVPFVPIR KKGKLPGATI EASYVKEYGE DRVEIQEGAI
KNGDIVFLID DLLATGGTLR AATDLVVKAG GKVGEAFVLI ELAPLNGRSK LPDVNLTTLI
SYDSA