ISP_PAEPO
ID ISP_PAEPO Reviewed; 326 AA.
AC P29139;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Intracellular serine protease;
DE EC=3.4.21.-;
GN Name=isp;
OS Paenibacillus polymyxa (Bacillus polymyxa).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1406;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 16-35.
RC STRAIN=72;
RX PubMed=1834632; DOI=10.1128/jb.173.21.6820-6825.1991;
RA Takekawa S., Uozumi N., Tsukagoshi N., Udaka S.;
RT "Proteases involved in generation of beta- and alpha-amylases from a large
RT amylase precursor in Bacillus polymyxa.";
RL J. Bacteriol. 173:6820-6825(1991).
CC -!- FUNCTION: Involved in the generation of beta- and alpha-amylases from
CC the large amylase precursor.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000305}.
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DR EMBL; D00862; BAA00735.1; -; Genomic_DNA.
DR PIR; C41335; C41335.
DR AlphaFoldDB; P29139; -.
DR SMR; P29139; -.
DR STRING; 1052684.PPM_2049; -.
DR MEROPS; S08.030; -.
DR eggNOG; COG1404; Bacteria.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07477; Peptidases_S8_Subtilisin_subset; 1.
DR Gene3D; 3.40.50.200; -; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034202; Subtilisin_Carlsberg-like.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; SSF52743; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Hydrolase; Protease; Serine protease.
FT CHAIN 1..326
FT /note="Intracellular serine protease"
FT /id="PRO_0000076409"
FT DOMAIN 23..303
FT /note="Peptidase S8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT ACT_SITE 49
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT ACT_SITE 86
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
FT ACT_SITE 244
FT /note="Charge relay system"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 326 AA; 35174 MW; 8DD2C7C910370F13 CRC64;
MERKVHIIPY QVIKQEQQVN EIPRGVEMIQ APAVWNQTRG RGVKVAVLDT GCDADHPDLK
ARIIGGRNFT DDDEGDPEIF KDYNGHGTHV AGTIAATENE NGVVGVAPEA DLLIIKVLNK
QGSGQYDWII QGIYYAIEQK VDIISMSLGG PEDVPELHEA VKKAVASQIL VMCAAGNEGD
GDDRTDELGY PGCYNEVISV GAINFDRHAS EFSNSNNEVD LVAPGEDILS TVPGGKYATF
SGTSMATPHV AGALALIKQL ANASFERDLT EPELYAQLIK RTIPLGNSPK MEGNGLLYLT
AVEELSRIFD TQRVAGILST ASLKVK