ID   IST1L_DICDI             Reviewed;         369 AA.
AC   Q54I39;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=IST1-like protein;
GN   ORFNames=DDB_G0289029;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the IST1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000129; EAL62930.1; -; Genomic_DNA.
DR   RefSeq; XP_636432.1; XM_631340.1.
DR   AlphaFoldDB; Q54I39; -.
DR   SMR; Q54I39; -.
DR   STRING; 44689.DDB0304889; -.
DR   PaxDb; Q54I39; -.
DR   EnsemblProtists; EAL62930; EAL62930; DDB_G0289029.
DR   GeneID; 8626924; -.
DR   KEGG; ddi:DDB_G0289029; -.
DR   dictyBase; DDB_G0289029; -.
DR   eggNOG; KOG2027; Eukaryota.
DR   HOGENOM; CLU_037652_0_0_1; -.
DR   InParanoid; Q54I39; -.
DR   OMA; TEACREE; -.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-9668328; Sealing of the nuclear envelope (NE) by ESCRT-III.
DR   PRO; PR:Q54I39; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:InterPro.
DR   Gene3D; 1.20.1260.60; -; 1.
DR   InterPro; IPR005061; Ist1.
DR   InterPro; IPR042277; IST1-like.
DR   PANTHER; PTHR12161; PTHR12161; 1.
DR   Pfam; PF03398; Ist1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..369
FT                   /note="IST1-like protein"
FT                   /id="PRO_0000327596"
FT   REGION          224..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          12..59
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        243..343
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   369 AA;  42515 MW;  2F7B0A48F9135099 CRC64;
     MFGFGPSYDS YKLKVQLKLA VSRIQILKNK KANIVRDEKR NVAELLRKKN EESARIRVET
     IIRDEYLIEC FQIIEVLCEL LHARINLINA TTEMPLEMKE SIFTLVYSSQ RIQIPELEQI
     KNQLKAKYGK GLENEANCHC STHVNPKIVH KLSYATPDPS IIFQTLSEIA EKFNVDWCGS
     DYPPPPQLIM PQPIIVQQQP QILQPPPQII HHQQQPQILQ PPPQIIQQQQ QPQMPSFPIM
     SPPQQPTFSQ IQHQQQIQQQ YQQQQQSPQF PSAPPSFYNN NSGNQTPQFP TISTNNSDGY
     SNDKFNNGNN NYNNNNNNNN NNNNNNNHNN NNNNNNNIPP PYQPSSDTGY PDYDELTARF
     EALKRSNDF