ID   ISTA_SHISO              Reviewed;         315 AA.
AC   P16944;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Transposase for insertion sequence element IS640;
GN   Name=istA;
OS   Shigella sonnei.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=624;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2824781; DOI=10.1016/0022-2836(87)90023-4;
RA   Matsutani S., Ohtsubo H., Maeda Y., Ohtsubo E.;
RT   "Isolation and characterization of IS elements repeated in the bacterial
RT   chromosome.";
RL   J. Mol. Biol. 196:445-455(1987).
CC   -!- FUNCTION: Involved in the transposition of the insertion sequence.
CC   -!- SIMILARITY: Belongs to the transposase IS21/IS408/IS1162 family.
CC       {ECO:0000305}.
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DR   EMBL; X05956; CAA29390.1; -; Genomic_DNA.
DR   PIR; S03416; S03416.
DR   AlphaFoldDB; P16944; -.
DR   STRING; 216599.GCA_000283715_00722; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR017894; HTH_IS21_transposase_type.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00665; rve; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50531; HTH_IS21; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   3: Inferred from homology;
KW   DNA recombination; DNA-binding; Transposable element; Transposition.
FT   CHAIN           1..315
FT                   /note="Transposase for insertion sequence element IS640"
FT                   /id="PRO_0000075461"
FT   DOMAIN          5..66
FT                   /note="HTH IS21-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00615"
FT   DOMAIN          111..285
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
SQ   SEQUENCE   315 AA;  37544 MW;  DB92FEC6777D1D42 CRC64;
     MLSREDFYMI KQMRHEGAYI VDIATQIGCS ERTVRRYLKY PEPPARKTRH KMVKLKPFMD
     YIDMRLAENV WNSEVIFAEI KAMGYTGGRS MLRYYIQPKR KMRPSKRTVR FETQPGYQLQ
     HDWGEVEVEV AGQRCKVNFA VNTLGFSRSF HVFAAPKHDA EHTYESLVRA FRYFGGCVKT
     VLVDNQKAAV LKNNNGKVVF NSGFLLLADH YNFLPRACRP RRARTKGKVE RMVKYLKENF
     FVRYRRFDSF THVNQQLEQW IADVADKREL RQFKETPEQR SRWSRNICSV TGYRLRYQLL
     RYPPCVLGQL YRGWW