ISY1_ASHGO
ID ISY1_ASHGO Reviewed; 240 AA.
AC Q753F1;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Pre-mRNA-splicing factor ISY1;
GN Name=ISY1; OrderedLocusNames=AFR363W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Involved in nuclear pre-mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ISY1 family. {ECO:0000305}.
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DR EMBL; AE016819; AAS53734.1; -; Genomic_DNA.
DR RefSeq; NP_985910.1; NM_211265.1.
DR AlphaFoldDB; Q753F1; -.
DR SMR; Q753F1; -.
DR STRING; 33169.AAS53734; -.
DR PRIDE; Q753F1; -.
DR EnsemblFungi; AAS53734; AAS53734; AGOS_AFR363W.
DR GeneID; 4622180; -.
DR KEGG; ago:AGOS_AFR363W; -.
DR eggNOG; KOG3068; Eukaryota.
DR HOGENOM; CLU_043453_2_1_1; -.
DR InParanoid; Q753F1; -.
DR OMA; IPSCEKW; -.
DR Proteomes; UP000000591; Chromosome VI.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0071020; C:post-spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IEA:EnsemblFungi.
DR GO; GO:0000384; F:first spliceosomal transesterification activity; IEA:EnsemblFungi.
DR GO; GO:0000350; P:generation of catalytic spliceosome for second transesterification step; IBA:GO_Central.
DR GO; GO:0000389; P:mRNA 3'-splice site recognition; IBA:GO_Central.
DR Gene3D; 1.10.287.660; -; 1.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR InterPro; IPR009360; Isy1.
DR InterPro; IPR037200; Isy1_sf.
DR PANTHER; PTHR13021; PTHR13021; 1.
DR Pfam; PF06246; Isy1; 1.
DR SUPFAM; SSF140102; SSF140102; 1.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Spliceosome.
FT CHAIN 1..240
FT /note="Pre-mRNA-splicing factor ISY1"
FT /id="PRO_0000192963"
SQ SEQUENCE 240 AA; 28562 MW; 5EDE311C990A8619 CRC64;
MSRNVDKANS VLARYQELVA ENTSGYKDYS RFKRPTAVHR ISNLEEAQRW RAEVVKDIGN
KVTQIHDPSL NEMQIEDINN ELNRLFQEKM RWESHIRRNL RGPDYRRMKQ GLNTTGGTVI
NGTRYFGRAL ELPHVQELLQ QQQQQRVKQQ NQKQREQELR AKVRQWEEEL GPDYYGEDVP
PGMQEYEAQR SRELQDILRS AAGRAPQVQI PLFERLPTQE EVEGWLVERR RKRLQERLDL
