ID   ISY1_CANGA              Reviewed;         203 AA.
AC   Q6FR30;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Pre-mRNA-splicing factor ISY1;
GN   Name=ISY1; OrderedLocusNames=CAGL0I01364g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ISY1 family. {ECO:0000305}.
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DR   EMBL; CR380955; CAG60251.1; -; Genomic_DNA.
DR   RefSeq; XP_447314.1; XM_447314.1.
DR   AlphaFoldDB; Q6FR30; -.
DR   SMR; Q6FR30; -.
DR   STRING; 5478.XP_447314.1; -.
DR   EnsemblFungi; CAG60251; CAG60251; CAGL0I01364g.
DR   GeneID; 2889122; -.
DR   KEGG; cgr:CAGL0I01364g; -.
DR   CGD; CAL0132670; CAGL0I01364g.
DR   VEuPathDB; FungiDB:CAGL0I01364g; -.
DR   eggNOG; KOG3068; Eukaryota.
DR   HOGENOM; CLU_043453_2_1_1; -.
DR   InParanoid; Q6FR30; -.
DR   Proteomes; UP000002428; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000350; P:generation of catalytic spliceosome for second transesterification step; IEA:InterPro.
DR   Gene3D; 1.10.287.660; -; 1.
DR   InterPro; IPR029012; Helix_hairpin_bin_sf.
DR   InterPro; IPR009360; Isy1.
DR   InterPro; IPR037200; Isy1_sf.
DR   PANTHER; PTHR13021; PTHR13021; 1.
DR   Pfam; PF06246; Isy1; 1.
DR   SUPFAM; SSF140102; SSF140102; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..203
FT                   /note="Pre-mRNA-splicing factor ISY1"
FT                   /id="PRO_0000192966"
SQ   SEQUENCE   203 AA;  24187 MW;  E27139A05D23CD16 CRC64;
     MSRNVDKSQT VLALYQEHKA ESRRDYNRYK RPRVESVRDP AEAREWYKQT LREVGECTNR
     LYDPLLSEEQ VRECNARVNQ LIQESQRWSR HLRRFKQRQR PPVYGGVVVN GVRYIGRARE
     LPEARKRPTA ARQFTVKRAK YVDFSDNGDF SDNGDYRGTS ERLRKAHGIA QQESVLVEPP
     TQQQMEEYLV ERRKRQLLHQ LNL