ID   ISY1_DEBHA              Reviewed;         298 AA.
AC   Q6BU51;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Pre-mRNA-splicing factor ISY1;
GN   Name=ISY1; OrderedLocusNames=DEHA2C13574g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ISY1 family. {ECO:0000305}.
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DR   EMBL; CR382135; CAG86345.2; -; Genomic_DNA.
DR   RefSeq; XP_458268.2; XM_458268.1.
DR   AlphaFoldDB; Q6BU51; -.
DR   STRING; 4959.XP_458268.2; -.
DR   EnsemblFungi; CAG86345; CAG86345; DEHA2C13574g.
DR   GeneID; 2900042; -.
DR   KEGG; dha:DEHA2C13574g; -.
DR   VEuPathDB; FungiDB:DEHA2C13574g; -.
DR   eggNOG; KOG3068; Eukaryota.
DR   HOGENOM; CLU_043453_2_1_1; -.
DR   InParanoid; Q6BU51; -.
DR   OMA; WESQINI; -.
DR   OrthoDB; 1513531at2759; -.
DR   Proteomes; UP000000599; Chromosome C.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000350; P:generation of catalytic spliceosome for second transesterification step; IEA:InterPro.
DR   Gene3D; 1.10.287.660; -; 1.
DR   InterPro; IPR029012; Helix_hairpin_bin_sf.
DR   InterPro; IPR009360; Isy1.
DR   InterPro; IPR037200; Isy1_sf.
DR   PANTHER; PTHR13021; PTHR13021; 1.
DR   Pfam; PF06246; Isy1; 1.
DR   SUPFAM; SSF140102; SSF140102; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..298
FT                   /note="Pre-mRNA-splicing factor ISY1"
FT                   /id="PRO_0000192968"
SQ   SEQUENCE   298 AA;  34472 MW;  B75B62C273ABBC69 CRC64;
     MSRNTEKAQS SLNRFQALKN KEAGVLESNP NFRPKYVQSV DSLPQAEKWR STIIGEISVK
     LTKIQDPALN EYQIRDINDS LNKLFNEKRS WEYHIKNLGG ADYMHFNKDF NNAGKLSQLD
     SSGSHIKGYR YFGRAKELPD VKEVLMLQQK KGHANKSKHA KELEQNRLLN EQDQRIKADY
     YGVYDEINDG NDDIIASNER DIINQVNEVL GDEIIKPVDD INEYYVAHKA QGVDNLIEFE
     KNRGKKLFRK FKNNQHNDEA DSNVITNFEK EVPTSDEVTK WIVNKKRAEL IARLGINK