ID   ISY1_MAGO7              Reviewed;         246 AA.
AC   Q51LS1; A4RBQ8; G4NIV9; Q2KFW0;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Pre-mRNA-splicing factor ISY1;
GN   Name=ISY1; ORFNames=MGCH7_ch7g575, MGG_02820;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ISY1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAQ71168.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CM000230; EAQ71168.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CM001237; EHA46175.1; -; Genomic_DNA.
DR   RefSeq; XP_003720918.1; XM_003720870.1.
DR   AlphaFoldDB; Q51LS1; -.
DR   SMR; Q51LS1; -.
DR   STRING; 318829.MGG_02820T0; -.
DR   PRIDE; Q51LS1; -.
DR   EnsemblFungi; MGG_02820T0; MGG_02820T0; MGG_02820.
DR   GeneID; 2682373; -.
DR   KEGG; mgr:MGG_02820; -.
DR   VEuPathDB; FungiDB:MGG_02820; -.
DR   eggNOG; KOG3068; Eukaryota.
DR   HOGENOM; CLU_043453_2_0_1; -.
DR   InParanoid; Q51LS1; -.
DR   OMA; IPSCEKW; -.
DR   OrthoDB; 1513531at2759; -.
DR   Proteomes; UP000009058; Chromosome 7.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000974; C:Prp19 complex; IEA:EnsemblFungi.
DR   GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0000350; P:generation of catalytic spliceosome for second transesterification step; IEA:InterPro.
DR   Gene3D; 1.10.287.660; -; 1.
DR   InterPro; IPR029012; Helix_hairpin_bin_sf.
DR   InterPro; IPR009360; Isy1.
DR   InterPro; IPR037200; Isy1_sf.
DR   PANTHER; PTHR13021; PTHR13021; 1.
DR   Pfam; PF06246; Isy1; 1.
DR   SUPFAM; SSF140102; SSF140102; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..246
FT                   /note="Pre-mRNA-splicing factor ISY1"
FT                   /id="PRO_0000192971"
FT   REGION          196..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   246 AA;  28041 MW;  ED3F0C7C6EDADCA3 CRC64;
     MARNSEKAQS MLFRFREAQA ADLGIIDAGR TRRPRAITEQ DSIPACEKWR GQVLKDISRK
     VSRIQESSLS DYQIRDLNDE INKLMREKHM WEVQIRNLGG PNYTRAGGAK VYDEAGKEIG
     GAGRGYRYFG RAKELPGVKE LFEAARAKKG DEKPLEARDD LRKQVDAAYY GYSPDEEDDE
     LLAYEAAKEK EAFENLADNR KGEQLPPGWE PLPGDNGDGK GWELPTVEEV QQELINRRKQ
     RLLNQL