ID   ISY1_YARLI              Reviewed;         220 AA.
AC   Q6C9I7;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Pre-mRNA-splicing factor ISY1;
GN   Name=ISY1; OrderedLocusNames=YALI0D10901g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ISY1 family. {ECO:0000305}.
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DR   EMBL; CR382130; CAG80863.1; -; Genomic_DNA.
DR   RefSeq; XP_502675.1; XM_502675.1.
DR   AlphaFoldDB; Q6C9I7; -.
DR   SMR; Q6C9I7; -.
DR   STRING; 4952.CAG80863; -.
DR   PRIDE; Q6C9I7; -.
DR   EnsemblFungi; CAG80863; CAG80863; YALI0_D10901g.
DR   GeneID; 2910445; -.
DR   KEGG; yli:YALI0D10901g; -.
DR   VEuPathDB; FungiDB:YALI0_D10901g; -.
DR   HOGENOM; CLU_043453_2_0_1; -.
DR   InParanoid; Q6C9I7; -.
DR   OMA; MARSQEK; -.
DR   Proteomes; UP000001300; Chromosome D.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0071020; C:post-spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0000350; P:generation of catalytic spliceosome for second transesterification step; IBA:GO_Central.
DR   GO; GO:0000389; P:mRNA 3'-splice site recognition; IBA:GO_Central.
DR   Gene3D; 1.10.287.660; -; 1.
DR   InterPro; IPR029012; Helix_hairpin_bin_sf.
DR   InterPro; IPR009360; Isy1.
DR   InterPro; IPR037200; Isy1_sf.
DR   PANTHER; PTHR13021; PTHR13021; 1.
DR   Pfam; PF06246; Isy1; 1.
DR   SUPFAM; SSF140102; SSF140102; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..220
FT                   /note="Pre-mRNA-splicing factor ISY1"
FT                   /id="PRO_0000192975"
SQ   SEQUENCE   220 AA;  25196 MW;  B172423C76C30B7B CRC64;
     MSRNSEKQGS MLHRFQQQQA NAAGLLDVGR TVRPTYISGV ESLPQAEKWR SQVMKEISRK
     VTKIQDPALS DFQLRDLNDE INKLMSERHR WDLQIRSLGG PNYASFGGKK RGYQYYGRAR
     ELPGVSEMLQ SQKKDDTKKS GDFYIPPKNL NMVYFGYADD NVTGLMEFEK QRESELQDML
     AGKPDEDSGF VVGDITVPEE GDLEARLLEE RKRRVQALLD