ID   ITAS_BPT7               Reviewed;          89 AA.
AC   P03785;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   23-FEB-2022, entry version 66.
DE   RecName: Full=Inhibitor of toxin/antitoxin system;
DE   AltName: Full=Gene product 4.5;
DE            Short=Gp4.5;
GN   OrderedLocusNames=4.5;
OS   Escherichia phage T7 (Bacteriophage T7).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus.
OX   NCBI_TaxID=10760;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=6864790; DOI=10.1016/s0022-2836(83)80282-4;
RA   Dunn J.J., Studier F.W.;
RT   "Complete nucleotide sequence of bacteriophage T7 DNA and the locations of
RT   T7 genetic elements.";
RL   J. Mol. Biol. 166:477-535(1983).
RN   [2]
RP   FUNCTION, AND INTERACTION WITH HOST LON.
RX   PubMed=23478446; DOI=10.1016/j.molcel.2013.02.002;
RA   Sberro H., Leavitt A., Kiro R., Koh E., Peleg Y., Qimron U., Sorek R.;
RT   "Discovery of functional toxin/antitoxin systems in bacteria by shotgun
RT   cloning.";
RL   Mol. Cell 50:136-148(2013).
CC   -!- FUNCTION: Plays a role in the inhibition of the host toxin-antitoxin
CC       (TA) system. These modules made by the host and composed of a toxic
CC       gene and a neutralizing gene play role in stress response and
CC       programmed cell death. Gp4.5 interacts with the host protease lon to
CC       neutralize the degradation of the antitoxin that would result in the
CC       activation of the toxin and the destruction of the bacteria.
CC       {ECO:0000269|PubMed:23478446}.
CC   -!- SUBUNIT: Interacts with host lon protease; this interaction prevents
CC       the degradation of antitoxin by lon and thus the toxin activation.
CC       {ECO:0000269|PubMed:23478446}.
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DR   EMBL; V01146; CAA24410.1; -; Genomic_DNA.
DR   PIR; A04410; W4BP57.
DR   RefSeq; NP_041980.1; NC_001604.1.
DR   SMR; P03785; -.
DR   IntAct; P03785; 2.
DR   MINT; P03785; -.
DR   GeneID; 1261059; -.
DR   KEGG; vg:1261059; -.
DR   Proteomes; UP000000840; Genome.
DR   InterPro; IPR035151; TA_inhibitor.
DR   Pfam; PF17574; TA_inhibitor; 1.
PE   1: Evidence at protein level;
KW   Host-virus interaction; Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..89
FT                   /note="Inhibitor of toxin/antitoxin system"
FT                   /id="PRO_0000106495"
SQ   SEQUENCE   89 AA;  10091 MW;  6BE245F92EBB3DAC CRC64;
     MSNVAETIRL SDTADQWNRR VHINVRNGKA TMVYRWKDSK SSKNHTQRMT LTDEQALRLV
     NALTKAAVTA IHEAGRVNEA MAILDKIDN