ID   ITB2_XENLA              Reviewed;          77 AA.
AC   Q09062;
DT   30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Integrin beta-2;
DE   Flags: Fragment;
GN   Name=itgb2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   TISSUE=Liver;
RX   PubMed=7693527; DOI=10.1006/dbio.1993.1304;
RA   Ransom D.G., Hens M.D., Desimone D.W.;
RT   "Integrin expression in early amphibian embryos: cDNA cloning and
RT   characterization of Xenopus beta 1, beta 2, beta 3, and beta 6 subunits.";
RL   Dev. Biol. 160:265-275(1993).
CC   -!- FUNCTION: Integrins are a large family of cell surface glycoproteins
CC       that mediate cell to cell and cell to matrix adhesion.
CC   -!- SUBUNIT: Dimer of an alpha and beta subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Detected at stage 25 and steadily increases, with
CC       high levels at the late tailbud stage. {ECO:0000269|PubMed:7693527}.
CC   -!- SIMILARITY: Belongs to the integrin beta chain family. {ECO:0000305}.
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DR   EMBL; L13592; AAA16354.1; -; mRNA.
DR   AlphaFoldDB; Q09062; -.
DR   SMR; Q09062; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR015812; Integrin_bsu.
DR   InterPro; IPR015439; Integrin_bsu-2.
DR   InterPro; IPR002369; Integrin_bsu_VWA.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10082; PTHR10082; 1.
DR   PANTHER; PTHR10082:SF15; PTHR10082:SF15; 1.
DR   Pfam; PF00362; Integrin_beta; 1.
DR   PRINTS; PR01186; INTEGRINB.
DR   SUPFAM; SSF53300; SSF53300; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Disulfide bond; Glycoprotein; Integrin; Membrane; Receptor;
KW   Reference proteome; Transmembrane.
FT   CHAIN           <1..>77
FT                   /note="Integrin beta-2"
FT                   /id="PRO_0000174220"
FT   CARBOHYD        54
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        36..43
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
FT   NON_TER         77
SQ   SEQUENCE   77 AA;  8455 MW;  C84CC279ED91EF6B CRC64;
     ALNGITKSAQ IGFGSFVDKT VLPFVNTHPE KLKNPCPEKN ENCQPPFSFK HILNLTANGK
     EFQDQVGKQG ISGNLDR