ID   ITF2_CHICK              Reviewed;          85 AA.
AC   Q90683;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Transcription factor 4;
DE            Short=TCF-4;
DE   AltName: Full=Class A helix-loop-helix transcription factor GE2;
DE   Flags: Fragment;
GN   Name=TCF4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Neural tube;
RX   PubMed=8261111; DOI=10.1111/j.1460-9568.1993.tb00498.x;
RA   Neuman T., Keen A., Knapik E., Shain D., Ross M., Nornes H.O., Zuber M.X.;
RT   "ME1 and GE1: basic helix-loop-helix transcription factors expressed at
RT   high levels in the developing nervous system and in morphogenetically
RT   active regions.";
RL   Eur. J. Neurosci. 5:311-318(1993).
CC   -!- FUNCTION: Transcription factor that binds to the immunoglobulin
CC       enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal
CC       differentiation. Binds to the E-box present in the somatostatin
CC       receptor 2 initiator element (SSTR2-INR) to activate transcription (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Forms homo- or heterooligomers with myogenin.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; U35054; AAA78932.1; -; mRNA.
DR   AlphaFoldDB; Q90683; -.
DR   SMR; Q90683; -.
DR   STRING; 9031.ENSGALP00000006977; -.
DR   PaxDb; Q90683; -.
DR   VEuPathDB; HostDB:geneid_396334; -.
DR   eggNOG; KOG3910; Eukaryota.
DR   InParanoid; Q90683; -.
DR   OrthoDB; 571132at2759; -.
DR   PhylomeDB; Q90683; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0070888; F:E-box binding; ISS:UniProtKB.
DR   GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           <1..>85
FT                   /note="Transcription factor 4"
FT                   /id="PRO_0000127259"
FT   DOMAIN          7..60
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          62..85
FT                   /note="Class A specific domain"
FT   NON_TER         1
FT   NON_TER         85
SQ   SEQUENCE   85 AA;  10056 MW;  03399B87BFD6B66D CRC64;
     KAEREKERRM ANNARERLRV RDINEAFKEL GRMVQLHLKS DKPQTKLLIL HQAVAVILSL
     EQQVRERNLN PKAACLKRRE EEKVS