ID   ITFG2_PONAB             Reviewed;         433 AA.
AC   Q5RBH8;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=KICSTOR complex protein ITFG2 {ECO:0000305};
DE   AltName: Full=Integrin-alpha FG-GAP repeat-containing protein 2 {ECO:0000250|UniProtKB:Q969R8};
GN   Name=ITFG2 {ECO:0000250|UniProtKB:Q969R8};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As part of the KICSTOR complex functions in the amino acid-
CC       sensing branch of the TORC1 signaling pathway. Recruits, in an amino
CC       acid-independent manner, the GATOR1 complex to the lysosomal membranes
CC       and allows its interaction with GATOR2 and the RAG GTPases. Functions
CC       upstream of the RAG GTPases and is required to negatively regulate
CC       mTORC1 signaling in absence of amino acids. In absence of the KICSTOR
CC       complex mTORC1 is constitutively localized to the lysosome and
CC       activated. The KICSTOR complex is also probably involved in the
CC       regulation of mTORC1 by glucose. {ECO:0000250|UniProtKB:Q969R8}.
CC   -!- SUBUNIT: Part of the KICSTOR complex composed of KPTN, ITFG2, KICS2 and
CC       SZT2. SZT2 probably serves as a link between the other three proteins
CC       in the KICSTOR complex and may mediate the direct interaction with the
CC       GATOR complex via GATOR1. The KICSTOR complex interacts directly with
CC       the GATOR1 complex and most probably indirectly with the GATOR2 complex
CC       in an amino acid-independent manner. {ECO:0000250|UniProtKB:Q969R8}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q969R8}.
CC       Note=Localization to lysosomes is amino acid-independent.
CC       {ECO:0000250|UniProtKB:Q969R8}.
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DR   EMBL; CR858670; CAH90882.1; -; mRNA.
DR   RefSeq; NP_001125504.1; NM_001132032.1.
DR   AlphaFoldDB; Q5RBH8; -.
DR   STRING; 9601.ENSPPYP00000004733; -.
DR   GeneID; 100172413; -.
DR   KEGG; pon:100172413; -.
DR   CTD; 55846; -.
DR   eggNOG; ENOG502QUBC; Eukaryota.
DR   HOGENOM; CLU_021730_0_0_1; -.
DR   InParanoid; Q5RBH8; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0140007; C:KICSTOR complex; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; ISS:UniProtKB.
DR   GO; GO:0042149; P:cellular response to glucose starvation; ISS:UniProtKB.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; ISS:UniProtKB.
DR   Gene3D; 2.130.10.130; -; 1.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR031793; KICSTOR_ITFG2.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR16317; PTHR16317; 1.
DR   Pfam; PF15907; Itfg2; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   SUPFAM; SSF69318; SSF69318; 1.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..433
FT                   /note="KICSTOR complex protein ITFG2"
FT                   /id="PRO_0000289294"
FT   REPEAT          19..48
FT                   /note="FG-GAP 1; atypical"
FT   REPEAT          126..155
FT                   /note="FG-GAP 2; atypical"
FT   MOD_RES         104
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q969R8"
FT   MOD_RES         220
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q969R8"
SQ   SEQUENCE   433 AA;  47880 MW;  3E8EFF8D286B4BA3 CRC64;
     MRSVSYVQRV ALEFSGSLFP HAICLGDVDN DTLNELVVGD TSGKVSVYKN DDSRPWLTCS
     CQGMLTCVGV GDVCNKGKNL LVAVSAEGWF HLFDLTPAKV LDASGHHETL IGEEQRPVFK
     QHIPANTKVM LISDIDGDGC RELVVGYTDR VVRAFRWEEL GEGPEHLTGQ LVSLKKWMLE
     GQVDSLSVTL GPLGLPELMV SQPGCAYAIL LCTWKKDTGS PPASEGPMDG SRETPAARDV
     VLHQTSGRIH NKNVSTHLTG NIKQGHGTES SGSGLFALCT LDGTLKLMEE MEEADKLLWS
     VQVDHQLFAL EKLDVTGNGH EEVVACAWDG QTYIIDHNRT VVRFQVDENI RAFCAGLYAC
     KEGRNSPCLV YVTFNQKIYV YWEVQLERME STNLVKLLET KPEYHSLLQE LGVDPDDLPV
     TRALLHQTLY HPD