ID   ITGBL_MOUSE             Reviewed;         494 AA.
AC   Q8VDV0; Q8BKJ4; Q8BMS0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Integrin beta-like protein 1;
DE   Flags: Precursor;
GN   Name=Itgbl1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J; TISSUE=Skin, and Spinal ganglion;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8VDV0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8VDV0-2; Sequence=VSP_032005, VSP_032006;
CC   -!- DOMAIN: Contains ten tandem EGF-like repeats strikingly similar to
CC       those found in the cysteine rich 'stalk-like' structure of integrin
CC       beta-subunits.
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DR   EMBL; AK029068; BAC26275.1; -; mRNA.
DR   EMBL; AK051773; BAC34761.1; -; mRNA.
DR   EMBL; AC154590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC160988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC161001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CT033773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC020152; AAH20152.1; -; mRNA.
DR   CCDS; CCDS27354.1; -. [Q8VDV0-1]
DR   RefSeq; NP_663442.2; NM_145467.2. [Q8VDV0-1]
DR   AlphaFoldDB; Q8VDV0; -.
DR   BioGRID; 230138; 2.
DR   STRING; 10090.ENSMUSP00000059019; -.
DR   GlyGen; Q8VDV0; 1 site.
DR   PhosphoSitePlus; Q8VDV0; -.
DR   MaxQB; Q8VDV0; -.
DR   PaxDb; Q8VDV0; -.
DR   PRIDE; Q8VDV0; -.
DR   ProteomicsDB; 269349; -. [Q8VDV0-1]
DR   ProteomicsDB; 269350; -. [Q8VDV0-2]
DR   Antibodypedia; 1503; 97 antibodies from 21 providers.
DR   DNASU; 223272; -.
DR   Ensembl; ENSMUST00000049681; ENSMUSP00000059019; ENSMUSG00000032925. [Q8VDV0-1]
DR   Ensembl; ENSMUST00000142161; ENSMUSP00000121659; ENSMUSG00000032925. [Q8VDV0-2]
DR   GeneID; 223272; -.
DR   KEGG; mmu:223272; -.
DR   UCSC; uc007vbu.2; mouse. [Q8VDV0-1]
DR   CTD; 9358; -.
DR   MGI; MGI:2443439; Itgbl1.
DR   VEuPathDB; HostDB:ENSMUSG00000032925; -.
DR   eggNOG; KOG1226; Eukaryota.
DR   GeneTree; ENSGT00980000198528; -.
DR   HOGENOM; CLU_1464446_0_0_1; -.
DR   InParanoid; Q8VDV0; -.
DR   OMA; CGNDCKK; -.
DR   OrthoDB; 18592at2759; -.
DR   PhylomeDB; Q8VDV0; -.
DR   TreeFam; TF332636; -.
DR   BioGRID-ORCS; 223272; 7 hits in 75 CRISPR screens.
DR   ChiTaRS; Itgbl1; mouse.
DR   PRO; PR:Q8VDV0; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; Q8VDV0; protein.
DR   Bgee; ENSMUSG00000032925; Expressed in vault of skull and 135 other tissues.
DR   ExpressionAtlas; Q8VDV0; baseline and differential.
DR   Genevisible; Q8VDV0; MM.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR   GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR   GO; GO:0033627; P:cell adhesion mediated by integrin; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR013111; EGF_extracell.
DR   InterPro; IPR027070; Integrin_b-like_p1.
DR   InterPro; IPR015812; Integrin_bsu.
DR   PANTHER; PTHR10082; PTHR10082; 1.
DR   PANTHER; PTHR10082:SF3; PTHR10082:SF3; 1.
DR   Pfam; PF07974; EGF_2; 3.
DR   SMART; SM00181; EGF; 6.
DR   PROSITE; PS00022; EGF_1; 5.
DR   PROSITE; PS01186; EGF_2; 5.
DR   PROSITE; PS00243; INTEGRIN_BETA; 9.
PE   2: Evidence at transcript level;
KW   Alternative splicing; EGF-like domain; Glycoprotein; Reference proteome;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..494
FT                   /note="Integrin beta-like protein 1"
FT                   /id="PRO_0000323023"
FT   REPEAT          51..95
FT                   /note="I"
FT   REPEAT          96..142
FT                   /note="II"
FT   REPEAT          143..184
FT                   /note="III"
FT   REPEAT          185..230
FT                   /note="IV"
FT   REPEAT          231..275
FT                   /note="V"
FT   REPEAT          276..326
FT                   /note="VI"
FT   REPEAT          327..367
FT                   /note="VII"
FT   REPEAT          368..414
FT                   /note="VIII"
FT   REPEAT          415..454
FT                   /note="IX"
FT   REPEAT          455..494
FT                   /note="X"
FT   REGION          51..494
FT                   /note="Cysteine-rich tandem repeats"
FT   CARBOHYD        405
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         197..210
FT                   /note="HGKCYCGNCYCEAG -> QGKGHIGCLICIII (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_032005"
FT   VAR_SEQ         211..494
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_032006"
FT   CONFLICT        95
FT                   /note="I -> V (in Ref. 3; AAH20152)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   494 AA;  53978 MW;  6192CDC83E7F9005 CRC64;
     MHPPGFRNFL LLVSSLLFIG LSAAPQSFLP SLRSLSGAPC RLSRAESERR CRAPGQPPGS
     ALCHDRGRCE CGVCICHVTE PGTYFGPLCE CHEWICETYD GKTCAGHGNC DCGKCKCDVG
     WSGEACQYPT KCDLTKKISN QMCKNSQDVI CSNAGTCHCG RCKCDNSDGH GLIYGKFCEC
     DDRECIDDET EEVCGGHGKC YCGNCYCEAG WHGDKCEFQC DITPWESKRR CTSPDGKVCS
     NRGTCVCGEC SCHDVDPTGD WGDIHGDTCE CDERDCRAVY DRYSDDFCSG HGQCNCGRCD
     CRAGWYGKKC EHPRNCPLSA EESTKKCQGS SDLPCSGRGR CECGRCTCYP PGDSRVYGKT
     CECDDRRCED LDGVVCGGHG MCSCGRCVCE KGWFGKLCQH LRKCNMTEEQ SRSLCESADG
     TLCSGKGSCH CGKCICSGEE WYISGEFCDC DDRDCDKHDG LICTGNGICS CGNCECWDGW
     NGNACEIWLG TEYP