ID   ITIH2_BOVIN             Reviewed;          50 AA.
AC   P56651;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Inter-alpha-trypsin inhibitor heavy chain H2;
DE            Short=ITI heavy chain H2;
DE            Short=ITI-HC2;
DE            Short=Inter-alpha-inhibitor heavy chain 2;
DE   Flags: Fragments;
GN   Name=ITIH2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Serum;
RX   PubMed=7504674; DOI=10.1016/s0021-9258(19)74373-7;
RA   Huang L., Yoneda M., Kimata K.;
RT   "A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of
RT   the inter alpha-trypsin inhibitor.";
RL   J. Biol. Chem. 268:26725-26730(1993).
CC   -!- FUNCTION: May act as a carrier of hyaluronan in serum or as a binding
CC       protein between hyaluronan and other matrix protein, including those on
CC       cell surfaces in tissues to regulate the localization, synthesis and
CC       degradation of hyaluronan which are essential to cells undergoing
CC       biological processes. {ECO:0000250}.
CC   -!- SUBUNIT: I-alpha-I plasma protease inhibitors are assembled from one or
CC       two heavy chains (HC) and one light chain, bikunin. Inter-alpha-
CC       inhibitor (I-alpha-I) is composed of ITIH1/HC1, ITIH2/HC2 and bikunin.
CC       {ECO:0000250|UniProtKB:P19823}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Phosphorylated by FAM20C in the extracellular medium.
CC       {ECO:0000250|UniProtKB:P19823}.
CC   -!- SIMILARITY: Belongs to the ITIH family. {ECO:0000305}.
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DR   AlphaFoldDB; P56651; -.
DR   PaxDb; P56651; -.
DR   PRIDE; P56651; -.
DR   eggNOG; ENOG502QPS2; Eukaryota.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Protease inhibitor; Reference proteome;
KW   Secreted; Serine protease inhibitor.
FT   CHAIN           <1..>50
FT                   /note="Inter-alpha-trypsin inhibitor heavy chain H2"
FT                   /id="PRO_0000140899"
FT   NON_CONS        28..29
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         50
SQ   SEQUENCE   50 AA;  5984 MW;  BCBA5F6B6B5A2159 CRC64;
     LHYQEVKWRK LGSYEHRLHL KPGRLAKHEL EVFNGYFVHF PAPENMIPIG