ID   ITIH5_BOVIN             Reviewed;         940 AA.
AC   A2VE29;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Inter-alpha-trypsin inhibitor heavy chain H5;
DE            Short=ITI heavy chain H5;
DE            Short=ITI-HC5;
DE            Short=Inter-alpha-inhibitor heavy chain 5;
DE   Flags: Precursor;
GN   Name=ITIH5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a tumor suppressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ITIH family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC133544; AAI33545.1; -; mRNA.
DR   RefSeq; NP_001095986.1; NM_001102516.1.
DR   AlphaFoldDB; A2VE29; -.
DR   SMR; A2VE29; -.
DR   STRING; 9913.ENSBTAP00000045691; -.
DR   PaxDb; A2VE29; -.
DR   PRIDE; A2VE29; -.
DR   GeneID; 534787; -.
DR   KEGG; bta:534787; -.
DR   CTD; 80760; -.
DR   eggNOG; ENOG502QPS2; Eukaryota.
DR   InParanoid; A2VE29; -.
DR   OrthoDB; 955432at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR010600; ITI_HC_C.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF06668; ITI_HC_C; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF13768; VWA_3; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Protease inhibitor; Reference proteome; Secreted;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..940
FT                   /note="Inter-alpha-trypsin inhibitor heavy chain H5"
FT                   /id="PRO_0000331407"
FT   DOMAIN          35..161
FT                   /note="VIT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00801"
FT   DOMAIN          295..478
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   REGION          207..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        97
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        127
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        231
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        421
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        508
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        694
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        778
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        795
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   940 AA;  104356 MW;  D247C3FA2E62F041 CRC64;
     MLPLLGLCFA LPLCAGLLEE ARSWEDTSDQ VGLRIPRQVR LLQRLKTKPL MTEFSVKSTI
     ISRYAFTTVA CRMLNRGSED QEVTFQMQIP AAAFITNFTA LIGDKVYQGE ITEREKRNGD
     KVKEKRNKTI EDNGEKGTET FRASAVLPSK DKAAFLLSYE ELLQRRLGKY EHVVSVRPQQ
     LVGRLTVEVT VLERPGIAEL EVLGLQNSRQ RGSGRGPDDS GPPPSTVINQ NETFAKVVFK
     PSVVQQAKIA QNGILGDFIV RYDVNREQSI GDIQVLDGYF VHYFAPKDLP PLPKNVVFVL
     DSSASMVGTK LRQTKDALFT ILHDLRPQDH FNIVGFSNRI KVWKDHLVSV TPNSIRDGKV
     YIHHMSPSGG TDINGALQRG IQLLNDYVAH NDIEDRSVSL VVFLTDGKPT VGETHTFKIL
     NNTREATRGR VCIFTVGIGA DVDFKLLEKL SLENCGLTRR VHEDHDARAQ LIGFYDEIRT
     PLLSDIRVDY PPSLVERATR TLFPNYFNGS EIVIAGKLVD RAMDRLHVEV TASNSKKFVV
     LKKDVPVEPR KVGIDVSQSP RPRGRGQEEP NHLERLWSYL TLKELLSAWL QSIEEPERER
     LRQEAQALAV NHHFLIPFTS MTLKSAPRTE APEAAYGMSS TSMATGPETV MQSLRGTHLQ
     PGPAVKKPYN PRIKISKTSA DGDPHFVVDF PLSNLTVCFN IDGEPGHILR LVSDHADSGV
     TVNGELIGAP APPNGHKKQR TYFRTITILV NKPERSYLEI TPSRVIVDGG DRLVLPCNQS
     AVVGRRGLEV SVSANASVTI SIQGTVAFVV LLHLYKKPAP YQRNHLGFYI ANGQGLSSNC
     HGLLGQFLNQ EARLIGLSKS PAHPPVPEAG ERSEAVLEVK GRQVPVVWKQ RRIYNGEEQV
     DCWFARNNAA GLIDGEYKGY LAAHPFDSET AFGPGLSQGL