ITIH5_HUMAN
ID ITIH5_HUMAN Reviewed; 942 AA.
AC Q86UX2; Q5T664; Q5T665; Q5T666; Q6AI60; Q6UXB7; Q8TF48; Q8WYV2; Q96K70;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 25-MAY-2022, entry version 135.
DE RecName: Full=Inter-alpha-trypsin inhibitor heavy chain H5;
DE Short=ITI heavy chain H5;
DE Short=ITI-HC5;
DE Short=Inter-alpha-inhibitor heavy chain 5;
DE Flags: Precursor;
GN Name=ITIH5; Synonyms=KIAA1953; ORFNames=PP14776, UNQ311/PRO354;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION, AND
RP VARIANT PRO-570.
RC TISSUE=Mammary gland;
RX PubMed=14744536; DOI=10.1016/j.canlet.2003.09.011;
RA Himmelfarb M., Klopocki E., Grube S., Staub E., Klaman I., Hinzmann B.,
RA Kristiansen G., Rosenthal A., Duerst M., Dahl E.;
RT "ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain
RT family is downregulated in breast cancer.";
RL Cancer Lett. 204:69-77(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS PRO-570 AND SER-925.
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND VARIANT PRO-570.
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 119-942 (ISOFORM 1), AND VARIANT
RP SER-925.
RC TISSUE=Brain;
RX PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXII. The
RT complete sequences of 50 new cDNA clones which code for large proteins.";
RL DNA Res. 8:319-327(2001).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-677 (ISOFORM 1), AND VARIANT
RP PRO-570.
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: May act as a tumor suppressor.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q86UX2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86UX2-2; Sequence=VSP_033190, VSP_033191;
CC Name=3;
CC IsoId=Q86UX2-3; Sequence=VSP_033188, VSP_033189;
CC Name=4;
CC IsoId=Q86UX2-4; Sequence=VSP_035727, VSP_035728, VSP_035729,
CC VSP_035730;
CC -!- TISSUE SPECIFICITY: Abundantly expressed in placenta. Less abundant
CC expression in mammary gland and ovary. Expression is barely detectable
CC levels in all other tissues tested. {ECO:0000269|PubMed:14744536}.
CC -!- INDUCTION: Down-regulated in breast tumors.
CC {ECO:0000269|PubMed:14744536}.
CC -!- SIMILARITY: Belongs to the ITIH family. {ECO:0000305}.
CC -!- CAUTION: Conflict in position 933 in the human genome assembly due to a
CC frameshift. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI12953.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAI12955.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAI16360.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAI16363.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY238437; AAO49812.1; -; mRNA.
DR EMBL; AY358426; AAQ88792.1; -; mRNA.
DR EMBL; AK027375; BAB55070.1; -; mRNA.
DR EMBL; AF318347; AAL55854.1; -; mRNA.
DR EMBL; AL158044; CAI12953.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AL355374; CAI12953.1; JOINED; Genomic_DNA.
DR EMBL; AL158044; CAI12955.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AL355374; CAI12955.1; JOINED; Genomic_DNA.
DR EMBL; AL355374; CAI16360.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AL158044; CAI16360.1; JOINED; Genomic_DNA.
DR EMBL; AL355374; CAI16362.1; -; Genomic_DNA.
DR EMBL; AL355374; CAI16363.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AL158044; CAI16363.1; JOINED; Genomic_DNA.
DR EMBL; CH471072; EAW86379.1; -; Genomic_DNA.
DR EMBL; AB075833; BAB85539.1; -; mRNA.
DR EMBL; CR627109; CAH10363.1; -; mRNA.
DR CCDS; CCDS31139.2; -. [Q86UX2-1]
DR CCDS; CCDS31140.2; -. [Q86UX2-3]
DR RefSeq; NP_001001851.1; NM_001001851.2.
DR RefSeq; NP_085046.5; NM_030569.6.
DR AlphaFoldDB; Q86UX2; -.
DR SMR; Q86UX2; -.
DR BioGRID; 123294; 16.
DR IntAct; Q86UX2; 9.
DR MINT; Q86UX2; -.
DR STRING; 9606.ENSP00000380333; -.
DR GlyConnect; 1422; 5 N-Linked glycans (1 site).
DR GlyGen; Q86UX2; 8 sites, 5 N-linked glycans (1 site).
DR iPTMnet; Q86UX2; -.
DR PhosphoSitePlus; Q86UX2; -.
DR BioMuta; ITIH5; -.
DR DMDM; 187609608; -.
DR jPOST; Q86UX2; -.
DR MassIVE; Q86UX2; -.
DR PaxDb; Q86UX2; -.
DR PeptideAtlas; Q86UX2; -.
DR PRIDE; Q86UX2; -.
DR ProteomicsDB; 69925; -. [Q86UX2-1]
DR ProteomicsDB; 69926; -. [Q86UX2-2]
DR ProteomicsDB; 69927; -. [Q86UX2-3]
DR ProteomicsDB; 69928; -. [Q86UX2-4]
DR DNASU; 80760; -.
DR GeneID; 80760; -.
DR KEGG; hsa:80760; -.
DR CTD; 80760; -.
DR DisGeNET; 80760; -.
DR GeneCards; ITIH5; -.
DR HGNC; HGNC:21449; ITIH5.
DR MIM; 609783; gene.
DR neXtProt; NX_Q86UX2; -.
DR PharmGKB; PA134899668; -.
DR eggNOG; ENOG502QPS2; Eukaryota.
DR InParanoid; Q86UX2; -.
DR OrthoDB; 955432at2759; -.
DR PhylomeDB; Q86UX2; -.
DR TreeFam; TF328982; -.
DR PathwayCommons; Q86UX2; -.
DR SignaLink; Q86UX2; -.
DR BioGRID-ORCS; 80760; 1 hit in 251 CRISPR screens.
DR ChiTaRS; ITIH5; human.
DR GenomeRNAi; 80760; -.
DR Pharos; Q86UX2; Tbio.
DR PRO; PR:Q86UX2; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q86UX2; protein.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Protease inhibitor; Reference proteome;
KW Secreted; Serine protease inhibitor; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..942
FT /note="Inter-alpha-trypsin inhibitor heavy chain H5"
FT /id="PRO_0000331408"
FT DOMAIN 35..161
FT /note="VIT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00801"
FT DOMAIN 295..478
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT REGION 116..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 231
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 421
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 508
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 776
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 795
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 862
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..449
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15498874"
FT /id="VSP_035727"
FT VAR_SEQ 1..214
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_033188"
FT VAR_SEQ 215..218
FT /note="RGED -> MRNY (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_033189"
FT VAR_SEQ 450..473
FT /note="LSLENCGLTRRVHEEEDAGSQLIG -> MRTYDTPGTSMCIIPDDPHRNPRR
FT (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15498874"
FT /id="VSP_035728"
FT VAR_SEQ 667..694
FT /note="YQPRIKISKTSVDGDPHFVVDFPLSRLT -> NSVKKKQNKTKKRHGRDGVF
FT PLHHLGIR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_033190"
FT VAR_SEQ 678..693
FT /note="VDGDPHFVVDFPLSRL -> GKAKDAVVCGLRVRDV (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15498874"
FT /id="VSP_035729"
FT VAR_SEQ 694..942
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15498874"
FT /id="VSP_035730"
FT VAR_SEQ 695..942
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_033191"
FT VARIANT 139
FT /note="E -> K (in dbSNP:rs12761771)"
FT /id="VAR_042847"
FT VARIANT 207
FT /note="N -> H (in dbSNP:rs36056263)"
FT /id="VAR_042848"
FT VARIANT 421
FT /note="N -> H (in dbSNP:rs36056263)"
FT /id="VAR_055973"
FT VARIANT 496
FT /note="V -> M (in dbSNP:rs35892621)"
FT /id="VAR_061276"
FT VARIANT 570
FT /note="T -> P (in dbSNP:rs2275069)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:14744536, ECO:0000269|PubMed:15498874,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_042849"
FT VARIANT 629
FT /note="R -> C (in dbSNP:rs34213756)"
FT /id="VAR_042850"
FT VARIANT 925
FT /note="F -> S (in dbSNP:rs10795551)"
FT /evidence="ECO:0000269|PubMed:11853319,
FT ECO:0000269|PubMed:14702039"
FT /id="VAR_055974"
FT CONFLICT 188
FT /note="D -> G (in Ref. 3; BAB55070)"
FT /evidence="ECO:0000305"
FT CONFLICT 337
FT /note="S -> P (in Ref. 3; BAB55070)"
FT /evidence="ECO:0000305"
FT CONFLICT 343
FT /note="W -> R (in Ref. 8; CAH10363)"
FT /evidence="ECO:0000305"
FT CONFLICT 936
FT /note="Q -> R (in Ref. 1; AAO49812)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 942 AA; 104576 MW; 1666BE1C9B90ED61 CRC64;
MLLLLGLCLG LSLCVGSQEE AQSWGHSSEQ DGLRVPRQVR LLQRLKTKPL MTEFSVKSTI
ISRYAFTTVS CRMLNRASED QDIEFQMQIP AAAFITNFTM LIGDKVYQGE ITEREKKSGD
RVKEKRNKTT EENGEKGTEI FRASAVIPSK DKAAFFLSYE ELLQRRLGKY EHSISVRPQQ
LSGRLSVDVN ILESAGIASL EVLPLHNSRQ RGSGRGEDDS GPPPSTVINQ NETFANIIFK
PTVVQQARIA QNGILGDFII RYDVNREQSI GDIQVLNGYF VHYFAPKDLP PLPKNVVFVL
DSSASMVGTK LRQTKDALFT ILHDLRPQDR FSIIGFSNRI KVWKDHLISV TPDSIRDGKV
YIHHMSPTGG TDINGALQRA IRLLNKYVAH SGIGDRSVSL IVFLTDGKPT VGETHTLKIL
NNTREAARGQ VCIFTIGIGN DVDFRLLEKL SLENCGLTRR VHEEEDAGSQ LIGFYDEIRT
PLLSDIRIDY PPSSVVQATK TLFPNYFNGS EIIIAGKLVD RKLDHLHVEV TASNSKKFII
LKTDVPVRPQ KAGKDVTGSP RPGGDGEGDT NHIERLWSYL TTKELLSSWL QSDDEPEKER
LRQRAQALAV SYRFLTPFTS MKLRGPVPRM DGLEEAHGMS AAMGPEPVVQ SVRGAGTQPG
PLLKKPYQPR IKISKTSVDG DPHFVVDFPL SRLTVCFNID GQPGDILRLV SDHRDSGVTV
NGELIGAPAP PNGHKKQRTY LRTITILINK PERSYLEITP SRVILDGGDR LVLPCNQSVV
VGSWGLEVSV SANANVTVTI QGSIAFVILI HLYKKPAPFQ RHHLGFYIAN SEGLSSNCHG
LLGQFLNQDA RLTEDPAGPS QNLTHPLLLQ VGEGPEAVLT VKGHQVPVVW KQRKIYNGEE
QIDCWFARNN AAKLIDGEYK DYLAFHPFDT GMTLGQGMSR EL
