ITIH5_MOUSE
ID ITIH5_MOUSE Reviewed; 952 AA.
AC Q8BJD1; Q3US68; Q80VG0;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Inter-alpha-trypsin inhibitor heavy chain H5;
DE Short=ITI heavy chain H5;
DE Short=ITI-HC5;
DE Short=Inter-alpha-inhibitor heavy chain 5;
DE Flags: Precursor;
GN Name=Itih5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye, Head, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May act as a tumor suppressor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ITIH family. {ECO:0000305}.
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DR EMBL; AK140756; BAE24467.1; -; mRNA.
DR EMBL; AK087428; BAC39871.1; -; mRNA.
DR EMBL; AK134707; BAE22250.1; -; mRNA.
DR EMBL; AL772367; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL953853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC043314; AAH43314.2; -; mRNA.
DR EMBL; BC062196; AAH62196.1; -; mRNA.
DR CCDS; CCDS15678.1; -.
DR RefSeq; NP_766059.1; NM_172471.2.
DR AlphaFoldDB; Q8BJD1; -.
DR SMR; Q8BJD1; -.
DR BioGRID; 229073; 2.
DR STRING; 10090.ENSMUSP00000026886; -.
DR GlyConnect; 2408; 3 N-Linked glycans (2 sites).
DR GlyGen; Q8BJD1; 8 sites, 3 N-linked glycans (2 sites).
DR iPTMnet; Q8BJD1; -.
DR PhosphoSitePlus; Q8BJD1; -.
DR EPD; Q8BJD1; -.
DR MaxQB; Q8BJD1; -.
DR PaxDb; Q8BJD1; -.
DR PeptideAtlas; Q8BJD1; -.
DR PRIDE; Q8BJD1; -.
DR ProteomicsDB; 269410; -.
DR Antibodypedia; 52114; 104 antibodies from 11 providers.
DR DNASU; 209378; -.
DR Ensembl; ENSMUST00000026886; ENSMUSP00000026886; ENSMUSG00000025780.
DR GeneID; 209378; -.
DR KEGG; mmu:209378; -.
DR UCSC; uc008ihr.1; mouse.
DR CTD; 80760; -.
DR MGI; MGI:1925751; Itih5.
DR VEuPathDB; HostDB:ENSMUSG00000025780; -.
DR eggNOG; ENOG502QPS2; Eukaryota.
DR GeneTree; ENSGT00940000158317; -.
DR HOGENOM; CLU_008101_0_1_1; -.
DR InParanoid; Q8BJD1; -.
DR OMA; VFLLMYE; -.
DR OrthoDB; 955432at2759; -.
DR PhylomeDB; Q8BJD1; -.
DR TreeFam; TF328982; -.
DR BioGRID-ORCS; 209378; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Itih5; mouse.
DR PRO; PR:Q8BJD1; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BJD1; protein.
DR Bgee; ENSMUSG00000025780; Expressed in vestibular membrane of cochlear duct and 267 other tissues.
DR Genevisible; Q8BJD1; MM.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Protease inhibitor; Reference proteome; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..952
FT /note="Inter-alpha-trypsin inhibitor heavy chain H5"
FT /id="PRO_0000331409"
FT DOMAIN 35..161
FT /note="VIT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00801"
FT DOMAIN 295..478
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT REGION 113..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 933..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 136
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 231
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 508
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 776
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 795
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 862
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 16
FT /note="E -> K (in Ref. 1; BAE24467)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 952 AA; 106749 MW; 38168BCBFDF758AE CRC64;
MLLLLGLCLG LPLFSESQEE ARSWDDTSEQ VVLRVPRQLR LLQRLKTKPL MAEFSVKSTI
ISRYAFTTVS CRMLNRASED QEAEFQMQIP ESAFITNFTM LIGDSVYRGE ITQKDKKSSE
SVKDKRNRTS DDNEENGSDM FKASLVIPSK DKAAFFLSYE ELLQRRLGKY EHSISVRPQQ
LVGRLTVEVD ILERSGITSL EVLPLHNSRK KGSGKAEGDV GPPPSTLINQ NETFAKVIFK
PTVVQQAKIA QNGILGDFIV RYDVEREQNI GDIQVLNGYF VHYFAPKNLP PLPKNVVFVL
DISASMVGAK LQQTREALVT ILNDLRPQDR FNIIGFSNRI KMWKDHLLPV TPDNIRNGKI
YMYHLSPTGG TDINGALQAA IKLLNNYVAQ NDIEDRSVSL IIFLTDGKPT FGETNTLKIL
SNTKEATRGQ ICIFTVGIGD DVDFKLLEKL SLENCGLTRR VHEEDKAGAQ LIGFYDEIRT
PLLSDIRIDY PPDVVEHATK TLFPNYFNGS EIVIAGKMVD KKFDQLHVEV TASNSKKFVI
LKRDIPVEFR KMGNDVSVTP GSARDGGKDL NHIERLWSYL TVKELLSSWR QSNSEQEKEQ
LRQKAQDLAL NYHFLTPFTS MKLRKPGLRT NQLEDTYGMS AATGPATVVQ NLREAGKQPE
PDLKKTYDPR IKISKTSVDG DPHFVVDFPL SKLTVCFNID GEPGDILRLV SDHLNSGVTV
NGELIGAPAP PNGHKKQRTY FRTITILINR PERSYLEITP SRVILDGGDR LVLPCNQSVV
VGSRGLEVSV SANANITVVI QGNIAFVILI HLYKNPAPFQ RDHLGFYIAN SRGLSDNCHG
LLGQFLNQDA KLVGAPEEYG KNLSNQPFPR AEGMPEAILK VKGRRVPVVW KQRKIYNGQA
QVDCWFDRNN AAKLIDGVYK DYLASHPFDT ESALGLSTPR KPETDRPHEE SV
