ITLN2_HUMAN
ID ITLN2_HUMAN Reviewed; 325 AA.
AC Q8WWU7; Q17RR2; Q5VYI0;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Intelectin-2;
DE AltName: Full=Endothelial lectin HL-2;
DE Flags: Precursor;
GN Name=ITLN2; ORFNames=UNQ2789/PRO7179;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Small intestine;
RX PubMed=11181563; DOI=10.1093/glycob/11.1.65;
RA Lee J.K., Schnee J., Pang M., Wolfert M., Baum L.G., Moremen K.W.,
RA Pierce M.;
RT "Human homologs of the Xenopus oocyte cortical granule lectin XL35.";
RL Glycobiology 11:65-73(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT HIS-103.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in the defense system against pathogens.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WWU7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WWU7-2; Sequence=VSP_055093;
CC -!- TISSUE SPECIFICITY: Expressed only in the small intestine.
CC {ECO:0000269|PubMed:11181563}.
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DR EMBL; AY065973; AAL58074.1; -; mRNA.
DR EMBL; AY358905; AAQ89264.1; -; mRNA.
DR EMBL; AL354714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL591806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471121; EAW52685.1; -; Genomic_DNA.
DR EMBL; BC117225; AAI17226.1; -; mRNA.
DR EMBL; BC143341; AAI43342.1; -; mRNA.
DR CCDS; CCDS1212.1; -. [Q8WWU7-1]
DR RefSeq; NP_543154.1; NM_080878.2. [Q8WWU7-1]
DR RefSeq; XP_011507512.1; XM_011509210.1. [Q8WWU7-1]
DR RefSeq; XP_011507513.1; XM_011509211.1.
DR AlphaFoldDB; Q8WWU7; -.
DR SMR; Q8WWU7; -.
DR BioGRID; 126772; 61.
DR IntAct; Q8WWU7; 3.
DR STRING; 9606.ENSP00000357008; -.
DR iPTMnet; Q8WWU7; -.
DR PhosphoSitePlus; Q8WWU7; -.
DR BioMuta; ITLN2; -.
DR DMDM; 55976554; -.
DR EPD; Q8WWU7; -.
DR jPOST; Q8WWU7; -.
DR MassIVE; Q8WWU7; -.
DR PaxDb; Q8WWU7; -.
DR PeptideAtlas; Q8WWU7; -.
DR PRIDE; Q8WWU7; -.
DR ProteomicsDB; 74936; -. [Q8WWU7-1]
DR Antibodypedia; 1671; 102 antibodies from 21 providers.
DR DNASU; 142683; -.
DR Ensembl; ENST00000368029.4; ENSP00000357008.3; ENSG00000158764.7. [Q8WWU7-1]
DR GeneID; 142683; -.
DR KEGG; hsa:142683; -.
DR MANE-Select; ENST00000368029.4; ENSP00000357008.3; NM_080878.3; NP_543154.1.
DR UCSC; uc001fxd.4; human. [Q8WWU7-1]
DR CTD; 142683; -.
DR GeneCards; ITLN2; -.
DR HGNC; HGNC:20599; ITLN2.
DR HPA; ENSG00000158764; Tissue enriched (intestine).
DR MIM; 609874; gene.
DR neXtProt; NX_Q8WWU7; -.
DR OpenTargets; ENSG00000158764; -.
DR PharmGKB; PA134879128; -.
DR VEuPathDB; HostDB:ENSG00000158764; -.
DR eggNOG; ENOG502QU6C; Eukaryota.
DR GeneTree; ENSGT00940000163851; -.
DR HOGENOM; CLU_066147_0_0_1; -.
DR InParanoid; Q8WWU7; -.
DR OMA; THVKSSC; -.
DR OrthoDB; 754383at2759; -.
DR PhylomeDB; Q8WWU7; -.
DR TreeFam; TF328530; -.
DR PathwayCommons; Q8WWU7; -.
DR SignaLink; Q8WWU7; -.
DR BioGRID-ORCS; 142683; 11 hits in 1059 CRISPR screens.
DR ChiTaRS; ITLN2; human.
DR GenomeRNAi; 142683; -.
DR Pharos; Q8WWU7; Tbio.
DR PRO; PR:Q8WWU7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8WWU7; protein.
DR Bgee; ENSG00000158764; Expressed in duodenum and 66 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070492; F:oligosaccharide binding; IBA:GO_Central.
DR Gene3D; 3.90.215.10; -; 1.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR SUPFAM; SSF56496; SSF56496; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Disulfide bond; Lectin; Metal-binding;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..325
FT /note="Intelectin-2"
FT /id="PRO_0000009149"
FT DOMAIN 44..267
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT BINDING 98
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:Q8WWA0"
FT BINDING 99
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:Q8WWA0"
FT BINDING 101
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:Q8WWA0"
FT BINDING 104
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:Q8WWA0"
FT BINDING 109
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:Q8WWA0"
FT BINDING 110
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:Q8WWA0"
FT BINDING 145
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:Q8WWA0"
FT BINDING 272
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000250|UniProtKB:Q8WWA0"
FT BINDING 274..275
FT /ligand="a carbohydrate"
FT /ligand_id="ChEBI:CHEBI:16646"
FT /evidence="ECO:0000250|UniProtKB:Q8WWA0"
FT BINDING 274
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000250|UniProtKB:Q8WWA0"
FT BINDING 294
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:Q8WWA0"
FT DISULFID 53..82
FT /evidence="ECO:0000250|UniProtKB:Q8WWA0"
FT DISULFID 106..292
FT /evidence="ECO:0000250|UniProtKB:Q8WWA0"
FT DISULFID 211..271
FT /evidence="ECO:0000250|UniProtKB:Q8WWA0"
FT DISULFID 263..277
FT /evidence="ECO:0000250|UniProtKB:Q8WWA0"
FT VAR_SEQ 26
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_055093"
FT VARIANT 103
FT /note="R -> H (in dbSNP:rs6680969)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_019926"
FT VARIANT 171
FT /note="Q -> R (in dbSNP:rs12090411)"
FT /id="VAR_049076"
SQ SEQUENCE 325 AA; 36212 MW; 283C9A12AED2EBFC CRC64;
MLSMLRTMTR LCFLLFFSVA TSGCSAAAAS SLEMLSREFE TCAFSFSSLP RSCKEIKERC
HSAGDGLYFL RTKNGVVYQT FCDMTSGGGG WTLVASVHEN DMRGKCTVGD RWSSQQGNKA
DYPEGDGNWA NYNTFGSAEA ATSDDYKNPG YYDIQAKDLG IWHVPNKSPM QHWRNSALLR
YRTNTGFLQR LGHNLFGIYQ KYPVKYRSGK CWNDNGPAIP VVYDFGDAKK TASYYSPYGQ
REFVAGFVQF RVFNNERAAN ALCAGIKVTG CNTEHHCIGG GGFFPQGKPR QCGDFSAFDW
DGYGTHVKSS CSREITEAAV LLFYR
