ITM2B_CHICK
ID ITM2B_CHICK Reviewed; 262 AA.
AC O42204;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Integral membrane protein 2B;
DE AltName: Full=Transmembrane protein E3-16;
GN Name=ITM2B;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Basilar papilla;
RA Heller S., Nguyen T.-P., Javed Z., Hudspeth A.J.;
RT "A screen for inner ear-specific mRNAs.";
RL Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in the induction of neurite outgrowth.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q9Y287}; Single-pass type II membrane protein
CC {ECO:0000250|UniProtKB:Q9Y287}. Cell membrane
CC {ECO:0000250|UniProtKB:Q9Y287}; Single-pass type II membrane protein
CC {ECO:0000250|UniProtKB:Q9Y287}. Endosome membrane
CC {ECO:0000250|UniProtKB:Q9Y287}; Single-pass type II membrane protein
CC {ECO:0000250|UniProtKB:Q9Y287}.
CC -!- TISSUE SPECIFICITY: Expressed in areas of chondro-osteogenic transition
CC and widely in the nervous system.
CC -!- SIMILARITY: Belongs to the ITM2 family. {ECO:0000305}.
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DR EMBL; AF017985; AAB70816.1; -; mRNA.
DR AlphaFoldDB; O42204; -.
DR SMR; O42204; -.
DR STRING; 9031.ENSGALP00000029511; -.
DR PaxDb; O42204; -.
DR VEuPathDB; HostDB:geneid_395969; -.
DR eggNOG; KOG4681; Eukaryota.
DR InParanoid; O42204; -.
DR PhylomeDB; O42204; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0001540; F:amyloid-beta binding; IBA:GO_Central.
DR GO; GO:0042985; P:negative regulation of amyloid precursor protein biosynthetic process; IBA:GO_Central.
DR InterPro; IPR007084; BRICHOS_dom.
DR InterPro; IPR040145; ITM2.
DR PANTHER; PTHR10962; PTHR10962; 1.
DR Pfam; PF04089; BRICHOS; 1.
DR SMART; SM01039; BRICHOS; 1.
DR PROSITE; PS50869; BRICHOS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Endosome; Glycoprotein; Golgi apparatus;
KW Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..262
FT /note="Integral membrane protein 2B"
FT /id="PRO_0000154825"
FT TOPO_DOM 1..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..262
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT DOMAIN 132..226
FT /note="BRICHOS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00255"
FT CARBOHYD 165
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 84
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT DISULFID 159..218
FT /evidence="ECO:0000250"
FT DISULFID 243..260
FT /evidence="ECO:0000250"
SQ SEQUENCE 262 AA; 30010 MW; DB3E93AE86605B57 CRC64;
MVKVSFNSAL AHKEAANKEE ENSQVLILPP DAKEPEDVVV PAGHKRAWCW CMCFGLAFML
AGVILGGAYL YKYFAFQQGG VYFCGIKYIE DGLSLPESGA QLKSARYHTI EQNIQILEEE
DVEFISVPVP EFADSDPADI VHDFHRRLTA YLDLSLDKCY VIPLNTSVVM PPKNFLELLI
NIKAGTYLPQ SYLIHEQMIV TDRIENVDQL GFFIYRLCRG KETYKLQRKE AMKGIQKREA
VNCRKIRHFE NRFAMETLIC EQ
