ITPI1_MOUSE
ID ITPI1_MOUSE Reviewed; 1034 AA.
AC Q14B48; Q8BUH5;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Protein ITPRID1 {ECO:0000305};
DE AltName: Full=Coiled-coil domain-containing protein 129;
DE AltName: Full=ITPR-interacting domain-containing protein 1 {ECO:0000305};
GN Name=Itprid1; Synonyms=Ccdc129 {ECO:0000312|MGI:MGI:2685304};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q14B48-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14B48-2; Sequence=VSP_022256;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC39386.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK085190; BAC39386.1; ALT_INIT; mRNA.
DR EMBL; BC116335; AAI16336.1; -; mRNA.
DR CCDS; CCDS39493.1; -. [Q14B48-1]
DR RefSeq; NP_001075134.1; NM_001081665.1. [Q14B48-1]
DR RefSeq; XP_017177013.1; XM_017321524.1. [Q14B48-1]
DR AlphaFoldDB; Q14B48; -.
DR STRING; 10090.ENSMUSP00000045332; -.
DR PhosphoSitePlus; Q14B48; -.
DR PaxDb; Q14B48; -.
DR PRIDE; Q14B48; -.
DR ProteomicsDB; 281240; -. [Q14B48-1]
DR ProteomicsDB; 281241; -. [Q14B48-2]
DR Antibodypedia; 12709; 52 antibodies from 13 providers.
DR Ensembl; ENSMUST00000044729; ENSMUSP00000045332; ENSMUSG00000037973. [Q14B48-1]
DR GeneID; 232016; -.
DR KEGG; mmu:232016; -.
DR UCSC; uc009cax.1; mouse. [Q14B48-1]
DR CTD; 223075; -.
DR MGI; MGI:2685304; Itprid1.
DR VEuPathDB; HostDB:ENSMUSG00000037973; -.
DR eggNOG; ENOG502QU3K; Eukaryota.
DR GeneTree; ENSGT00940000161762; -.
DR HOGENOM; CLU_313444_0_0_1; -.
DR InParanoid; Q14B48; -.
DR OMA; MKMVCQS; -.
DR OrthoDB; 159347at2759; -.
DR PhylomeDB; Q14B48; -.
DR TreeFam; TF331566; -.
DR BioGRID-ORCS; 232016; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q14B48; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q14B48; protein.
DR Bgee; ENSMUSG00000037973; Expressed in ganglionic eminence and 16 other tissues.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR InterPro; IPR029325; ITPR-bd.
DR InterPro; IPR029326; SSFA2_C.
DR InterPro; IPR043444; TESPA1-like.
DR PANTHER; PTHR17469; PTHR17469; 1.
DR Pfam; PF14722; KRAP_IP3R_bind; 1.
DR Pfam; PF14723; SSFA2_C; 1.
DR SMART; SM01257; KRAP_IP3R_bind; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..1034
FT /note="Protein ITPRID1"
FT /id="PRO_0000270964"
FT REGION 223..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 843..902
FT /evidence="ECO:0000255"
FT COMPBIAS 258..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..190
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022256"
SQ SEQUENCE 1034 AA; 115605 MW; 67E1B67D9B5F09AB CRC64;
MIMEELQGSD TPRAGLEMSK RDILRHTKRA WAPLDGHLLP DSEEENPMVT MYVQENSKQE
SIQQWLDSGF FVSVNENFQQ TINHTASLHE QGIIQMTVKD YMRSLHQFSE TPTLSRGTSF
NSCYSTTGVP QSIPEWLEFW EKDPVEILLD LGFGADEPDI CTQIPARFLG YSSAARGINI
HVFLEAQKQR MDFENPDLYG RFQQLEILDH VTNAFSSLLD GVKTQQNQHE EKAERQAMQN
PSSSGAKEHK RKMSQLLKRA SRQTSRMDGN PALSKSCKTE HEIPTLPTKP WDPRVELQVA
SISHDASQML PLIECGSAQV HNDLSPCPPL CPPPHALLDK PWPCSCTLAK QSPHTCLSEG
SVRRRNWKEK WNHMDRLKNL SHIVSKGPDS FEMEEVQSFE EDTGNPLILT SGIVGTRVDR
TNSCQSDSSG FLEELPELQP LQVSSMTGSQ SPTVCRGCKP RDQSHSPASQ QDSLQESYGS
KSKSMTSSSL LSQDWSTLEE NASASVVEEE LQLKAMEEPP EIVNPDMTLI KTIMVGEHPE
SVAGPVVTST STCNNTMGVL VTHVTEKEDR SVGHKGTRKM LIQRHHFESP RSFRIDQPSD
NFYHVDSEIT KTEDNCKVCP DTKQSSLVQE RPAQHSHQHR GAMPYKGDLV QTSEKSIPHL
DKPPGHVPTD SNAASSWSVT TQMSSNLVSA AQRVADLGTY NKGTAFECTP CDPLNTTDLK
LQTETRQVKD VAVQTYAHEC KLRPSHNDFI HGPRPLAKSI SLDTGFPSIS ATGFCHTIPA
HCCVCCHHCP NCQWRRQSPG PEPSICRHSL YSQAEDPKVQ FMKTLKILQD TTVRDLCSCT
VYEMETMKMV CQSFREHLEE IEQHFMGQQA LYPRDMSEEE REEAEYLRTL REALRQQVAE
LAFQLGDRAR QIKEGILLQL DLLCEELPEH CDNLPQCNWT EGKHGQRSCV QTHAVAPDPT
LPASSGQWTP CSGMTQPVAL SPSHLETRGG ISLQSPARAE SGPGPSLSHV GEKSLLDQSG
FDDLCTKCNV QEQL
