ID   ITP_ALHV1               Reviewed;         952 AA.
AC   O36413;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   23-FEB-2022, entry version 62.
DE   RecName: Full=Inner tegument protein {ECO:0000255|HAMAP-Rule:MF_04043};
GN   Name=63;
OS   Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Macavirus.
OX   NCBI_TaxID=654901;
OH   NCBI_TaxID=9927; Connochaetes taurinus (Blue wildebeest).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9261371; DOI=10.1128/jvi.71.9.6517-6525.1997;
RA   Ensser A., Pflanz R., Fleckenstein B.;
RT   "Primary structure of the alcelaphine herpesvirus 1 genome.";
RL   J. Virol. 71:6517-6525(1997).
CC   -!- FUNCTION: Plays an essential role in cytoplasmic secondary envelopment
CC       during viral egress. Interacts with the capsid via the large tegument
CC       protein/LTP and participates in its transport to the host trans-Golgi
CC       network (TGN) where secondary envelopment occurs. Modulates
CC       tegumentation and capsid accumulation at the viral assembly complex.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with the large tegument protein/LTP
CC       (via N-terminus). {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04043}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04043}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04043}. Host Golgi apparatus, host
CC       trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SIMILARITY: Belongs to the herpesviridae inner tegument protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
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DR   EMBL; AF005370; AAC58110.1; -; Genomic_DNA.
DR   PIR; T03158; T03158.
DR   RefSeq; NP_065562.1; NC_002531.1.
DR   PRIDE; O36413; -.
DR   GeneID; 911787; -.
DR   KEGG; vg:911787; -.
DR   Proteomes; UP000000941; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039701; P:microtubule-dependent intracellular transport of viral material towards cell periphery; IEA:UniProtKB-UniRule.
DR   GO; GO:0019068; P:virion assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04043; HSV_ITP; 1.
DR   InterPro; IPR007611; Herpes_U30.
DR   InterPro; IPR034738; HSV_ITP.
DR   Pfam; PF04523; Herpes_U30; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Reference proteome;
KW   Virion; Virion tegument.
FT   CHAIN           1..952
FT                   /note="Inner tegument protein"
FT                   /id="PRO_0000405769"
FT   REGION          490..952
FT                   /note="Interaction with large tegument protein"
FT                   /evidence="ECO:0000250|UniProtKB:P10221"
SQ   SEQUENCE   952 AA;  107067 MW;  2D5ECF7D47A1FEEE CRC64;
     MMENKRSLLK ITQNIQNVTS KLAKLREILD LEMKMIDATE LCNQQLVVKF LNSLPQEQGG
     LIEFVTTHYV YFLFKNCTLS PQFLERGTEH EEVVSKCLHL LKSAVECMSQ ITSDLFGCQG
     SGLLSNRNIL SELQLFLTWA QNVNRNSTEL TSLPTTPVQT FLCAEEIMSL LYLSKLYNTI
     PSVQFNMPNF QTMGVLEQWT ISLYTSTVGL PTGPYQLPNA TELACALVSR HADLFISPTH
     VSQPLLTFPF AKKRANLIFQ SYLNNPQASI TETGPLVQLR EADLQTLDTT FFFLYDYIFE
     ALSNNQAYSC SAATVNNFIA RCVDSLTDLG SNLLEASTAS RGPSNNIDAF KGFLLRAGLT
     EKNCSDFKTL LLLNKSNGHT QWKQFPKLLR LVTQLTLTAH YFYACLQQYS PTSLARCKIT
     DTLKMAAAEQ MVEYQASGSG KQSKPFEWTI PGILSFFIPQ PPTELLQVMS DNISSPYMQS
     FFWISAHRAW QLKPHTILQR ELSPTPLPSS PCNEEDVKKY CREIQVGDTA YQLNIVKCDT
     FELEFIKTHA FPILQNIFSM DLHIHRAMVQ LRWLITFAAD APPFLSTLRK PLILLYFQIN
     DIISQNRVDT SFINMLDYTK DVLTAVQEAV PSAEFSPNLI NYLFLTHFSS SLKILMDTVN
     EFVTETTTVA ESVASLARVG ATICHSVFSF NTRNDTLEFP IAGENGDEIF QISVPAFKST
     VANLQQNCYD VIVLLNESSR ELHASYLDLQ VISSDIDSMR NHSIKFDHAS LNFKGMKDFY
     IKCFALQNKL ASKIANTCCY SLTRRFAPLF EPELISLQTV ENILNFSDTV DDPSVFLSGI
     NQPMGCVPPN CQQGAVEKLS KQDVLDIREL APDFTEGASS APANATVIKH NFTGTFDKVS
     IDLDQSSLNT EFTFADKEYN LRTLRQLKLI FLEDLLSNTP QSPPPTDPAL TN