ID   ITP_EBVA8               Reviewed;        1240 AA.
AC   Q1HVH8;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   23-FEB-2022, entry version 42.
DE   RecName: Full=Inner tegument protein {ECO:0000255|HAMAP-Rule:MF_04043};
GN   ORFNames=BOLF1;
OS   Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=82830;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16490228; DOI=10.1016/j.virol.2006.01.015;
RA   Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J.;
RT   "The genome of Epstein-Barr virus type 2 strain AG876.";
RL   Virology 350:164-170(2006).
CC   -!- FUNCTION: Plays an essential role in cytoplasmic secondary envelopment
CC       during viral egress. Interacts with the capsid via the large tegument
CC       protein/LTP and participates in its transport to the host trans-Golgi
CC       network (TGN) where secondary envelopment occurs. Modulates
CC       tegumentation and capsid accumulation at the viral assembly complex.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with the large tegument protein/LTP
CC       (via N-terminus). {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04043}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04043}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04043}. Host Golgi apparatus, host
CC       trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SIMILARITY: Belongs to the herpesviridae inner tegument protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
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DR   EMBL; DQ279927; ABB89230.1; -; Genomic_DNA.
DR   RefSeq; YP_001129450.1; NC_009334.1.
DR   PRIDE; Q1HVH8; -.
DR   GeneID; 5176199; -.
DR   KEGG; vg:5176199; -.
DR   Proteomes; UP000007639; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039701; P:microtubule-dependent intracellular transport of viral material towards cell periphery; IEA:UniProtKB-UniRule.
DR   GO; GO:0019068; P:virion assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04043; HSV_ITP; 1.
DR   InterPro; IPR007611; Herpes_U30.
DR   InterPro; IPR034738; HSV_ITP.
DR   Pfam; PF04523; Herpes_U30; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Reference proteome;
KW   Virion; Virion tegument.
FT   CHAIN           1..1240
FT                   /note="Inner tegument protein"
FT                   /id="PRO_0000382435"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          619..1240
FT                   /note="Interaction with large tegument protein"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04043"
FT   REGION          673..709
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          963..984
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1091..1240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1150..1165
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1240 AA;  132813 MW;  1A0E3D0FEBA3C700 CRC64;
     MASAMESDSG GGSGGADAQP PLAEVDGGLA RVTRQLLLSG DDPAARLRAL MPLELGIFGL
     GDLAQPVLVR DFLNTLTLMS GHAYPAAVLR HHAYYLLRAA SFSRRSFGLG HLEAALDVLA
     SSLPPTTASP ATDDPLDGSR LIAETRALAA TYRRIIEEGS GEVLAVSGPT ATFAFVEELV
     ADTYLARWDA FPREGLSFYA FNAAKTTLGR WLVTVYAETN RYPWAAAGQG QPTAADIKAM
     AVELVEHSGG GAGGGEGEES GGGGLFHRPE SLSSVVASLP LARRRAVEIL GVYAEASGGQ
     TPPVAAVPVL AFDAARLRLL EPSGALFYDY VYEALLWDQT YGVPDSVIEA FLAGMAAEME
     ALAARVQEAA GSRASFSPAA IEQVATVLLS AGLNETVAGD YAMMLASVPR VSRSRWRWLE
     ATAALLESLS GFALHFFRLL PTASPTSRFA RVARAAYLRA EAEAVDRRAR RTSGPSTPAA
     APAATAVGVG AAADPWDAVT PLRIFIVPPP AAEYEQVAGD LSSELLRSLL WVRYSRLWQA
     PAPAPALPCK PPLLPGEQGR RQWTAAVAAA PRTDVEAYCR SLRAGQTARA DPAYVRSPFF
     PAAFIEFQIW PALRRVLSNE LPKTRSLAAL RWLVSFGSDL ALPSPELTRA RRPLELIYAT
     VWEIYDGAPP MPGESPQAVG LRPLNLEGEG KAGDAGAEGA EDEEGGGPWG LSSHDAVLRI
     MDAVREVSGI ISETISASER AAEAPPLAWP TSLFSLLFTL RYSTTAESLG LATRRFLVSG
     ETLSEDISRL TGAAWRLCSR PLLYDAETGR VQIPLATEEE EEAVVAVKEK SVSSSPRHYS
     TDLQTLKSVV EGIQDVCRDA AARWALATAD TATLRRRLLV PALRESRGIA DHPLWAHTSE
     PLRPDLEELN ERVEHALELG YSLTGALRRS VAYRFRDYTF ARLFQPPAID AERAEAIVRR
     DARPPPVFTP APRRLPQGGA DTPPPLSMDD ILYLGKSICK ALVDVLDHHP AAPETTPIKT
     YTPAMDLNPE QITVTPRSPS VLAAFARTAR VQTHHLVPAL TDDSPSPVGQ TPPPFRILPA
     KKLAAILLGN GRNASKRRAS RDLSPPPHGR WRAVLDSSPF SFSSSDFSDQ DEGEGGEADL
     RGVPGGGGEG AYEEDRERPS DIDTAARAQK VETSCPRRRS PRTTPSPSRR ASGGGGPDRG
     EAEAHTYPPY LSAAAAASRV RPRTRRGATR RPPRPTAEDE