ID   ITP_EBVG                Reviewed;        1239 AA.
AC   Q3KSU7;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   23-FEB-2022, entry version 42.
DE   RecName: Full=Inner tegument protein {ECO:0000255|HAMAP-Rule:MF_04043};
GN   ORFNames=BOLF1;
OS   Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=10376;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16306603; DOI=10.1128/jvi.79.24.15323-15330.2005;
RA   Zeng M.-S., Li D.-J., Liu Q.-L., Song L.-B., Li M.-Z., Zhang R.-H.,
RA   Yu X.-J., Wang H.-M., Ernberg I., Zeng Y.-X.;
RT   "Genomic sequence analysis of Epstein-Barr virus strain GD1 from a
RT   nasopharyngeal carcinoma patient.";
RL   J. Virol. 79:15323-15330(2005).
CC   -!- FUNCTION: Plays an essential role in cytoplasmic secondary envelopment
CC       during viral egress. Interacts with the capsid via the large tegument
CC       protein/LTP and participates in its transport to the host trans-Golgi
CC       network (TGN) where secondary envelopment occurs. Modulates
CC       tegumentation and capsid accumulation at the viral assembly complex.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with the large tegument protein/LTP
CC       (via N-terminus). {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04043}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04043}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04043}. Host Golgi apparatus, host
CC       trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SIMILARITY: Belongs to the herpesviridae inner tegument protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
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DR   EMBL; AY961628; AAY41103.1; -; Genomic_DNA.
DR   SMR; Q3KSU7; -.
DR   IntAct; Q3KSU7; 2.
DR   PRIDE; Q3KSU7; -.
DR   Proteomes; UP000007641; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039701; P:microtubule-dependent intracellular transport of viral material towards cell periphery; IEA:UniProtKB-UniRule.
DR   GO; GO:0019068; P:virion assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04043; HSV_ITP; 1.
DR   InterPro; IPR007611; Herpes_U30.
DR   InterPro; IPR034738; HSV_ITP.
DR   Pfam; PF04523; Herpes_U30; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Virion;
KW   Virion tegument.
FT   CHAIN           1..1239
FT                   /note="Inner tegument protein"
FT                   /id="PRO_0000382436"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          615..1239
FT                   /note="Interaction with large tegument protein"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04043"
FT   REGION          669..704
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          959..980
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1087..1239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1148..1175
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1239 AA;  132857 MW;  513AB9DD9EB8CFC2 CRC64;
     MASAMESDSG GGSGGADAQP PLAEVDGGLA RVTRQLLLSG DDPAARLRAL MPLELGIFGL
     GDLAQPVLVR DFLNTLTLMS GHAYPAAVLR HHAYYLLRAA SFSRRSFGLG HLEAALDVLA
     SSLPPTTASP ATDDPLDGSR LIADTRALAA EYRRIIEEGS GEVLAVSGPT ATFAFVEELV
     ADTYLARWDA FPREGLSFYA FNAAKTTLGR WLVTVYAETN RYPWAAAGQG QPTAADIKAM
     AVELVEHSGG RAGGGEGEES GGGGLFHRPE SLSSVVASLP LARRRAVEIL GVYAEASGGQ
     TPPVAAVPVL AFDAARLRLL EPSGALFYDY VYEALLWDQT YGVPDSVIEA FLAGMAAEME
     ALAARVQEAA GSRASFSPAA IEQVATVLLS AGLNETVAGD YAMMLASVPR VSRSRWRWLE
     ATAALLESLS GFALHFFRLL PTASPTSRFA RVARAAYLRA EAEAKDRRAR RTSGPSTPAA
     TAVGVGAVAD PWDAVTPLRI FIVPPPAAEY EQVAGDLSSE LLRSLLWVRY SRLWQAPAPA
     PALPCKPPLL PGEQGRRQWT AAVAAVPRTD VEAYCRSLRA GQTARADPAY VRSPFFPAAF
     IEFQIWPALR RVLSNELPKT RSLAALRWLV SFGSDLALPS PELTRARRPL ELIYATVWEI
     YDGAPPMPGE SPQAVGLRPL NLEGEGKAGD AGADGAEDEE GGGPWGLSSH DAVLRIMDAV
     REVSGIISET ISASERAAEA PPLAWPTSLF SLLFTLRYST TAESLGLATR RFLVSGETLS
     EDISRLTGAA WRLCSRPLLY DAETGRVQIP LATEEEEEAV VAVKEKSVSS SPRHYSTDLQ
     TLKSVVEGIQ DVCRDAAARW ALATADTATL RRRLLVPALR ESRGIADHPL WAHTSEPLRP
     DLEELNERVE HALELGYSLT GALRRSVAYR FRDYTFARLF QPPAIDAERA EAIVRRDARP
     PPVFTPAPRR LPQGGADTPP PLSMDDIMYL GKSICKALVD VLDHHPAAPE TTPIKTYTPA
     MDLNPEQITV TPRSPSVLAA FARTARVQTH HLVPALTDDS PSPVGQTPPP FRILPAKKLA
     AILLGNGRNA SKRRASRDLS PPPHGRWRAV LDSSPFSFSS SDFSDQDEGE GGKADLRGVP
     GGGGGGEGAY EEERERPSDI DTAARARKVE TSCPRRRSPR TTPSPSRRAS GGGGGPDRGE
     AEAHTCPPYL SAAAAASRVR PRTRRGATRR PPRPTAEDE