ID   ITP_EHV1B               Reviewed;        1020 AA.
AC   P28956; Q6S6P8;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   23-FEB-2022, entry version 70.
DE   RecName: Full=Inner tegument protein {ECO:0000255|HAMAP-Rule:MF_04043};
GN   OrderedLocusNames=23;
OS   Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=31520;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1318606; DOI=10.1016/0042-6822(92)90706-u;
RA   Telford E.A.R., Watson M.S., McBride K., Davison A.J.;
RT   "The DNA sequence of equine herpesvirus-1.";
RL   Virology 189:304-316(1992).
CC   -!- FUNCTION: Plays an essential role in cytoplasmic secondary envelopment
CC       during viral egress. Interacts with the capsid via the large tegument
CC       protein/LTP and participates in its transport to the host trans-Golgi
CC       network (TGN) where secondary envelopment occurs. Modulates
CC       tegumentation and capsid accumulation at the viral assembly complex.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with the large tegument protein/LTP
CC       (via N-terminus). {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04043}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04043}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04043}. Host Golgi apparatus, host
CC       trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SIMILARITY: Belongs to the herpesviridae inner tegument protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
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DR   EMBL; AY665713; AAT67280.1; -; Genomic_DNA.
DR   PIR; F36797; WZBEB5.
DR   RefSeq; YP_053068.1; NC_001491.2.
DR   SMR; P28956; -.
DR   GeneID; 1487542; -.
DR   KEGG; vg:1487542; -.
DR   Proteomes; UP000001189; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039701; P:microtubule-dependent intracellular transport of viral material towards cell periphery; IEA:UniProtKB-UniRule.
DR   GO; GO:0019068; P:virion assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04043; HSV_ITP; 1.
DR   InterPro; IPR005655; Herpes_UL37.
DR   InterPro; IPR034738; HSV_ITP.
DR   Pfam; PF03970; Herpes_UL37_1; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Reference proteome;
KW   Virion; Virion tegument.
FT   CHAIN           1..1020
FT                   /note="Inner tegument protein"
FT                   /id="PRO_0000116045"
FT   REGION          539..1020
FT                   /note="Interaction with large tegument protein"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04043"
SQ   SEQUENCE   1020 AA;  111611 MW;  926E9EBBCAE4B527 CRC64;
     MAREHGSMRA LVNSLAGLLG ETDTEVPSLE PAMLMVLKSS ISEFFLSTDT VSVDEAAELF
     PRLQFLACRA YAASHTPDAA MLAENLAGLV LWRIHQNWTD REMEAVDQMF VLLEIMNGES
     GVYMLSNNNL RISAKYGPSN MHLIVSTWLD TFRNVMSVAA KSTPDSLFNS KRMESIEEFS
     KPLVHAKFNL IYDMPFVQEG LRIVAKKINW ILPFGLMVKG YKDMSMAPLT RALFLLSLVD
     SYFPKGTATE GSMKALTAYF RELVRTIDNS AFVPITEVNA TPRTAYEVRV SSAIVHQNPY
     VTDTKAGMVA ERVRTDAEIL TSGALLSSGA LSAHATAVAK LLSSNEPDDV SSRARARVAE
     HASNTWETIQ ASTTPTQVVE ALVTAGFTST HCGILERVVV DYFTRLRSTA NSGPGRNDSL
     DYAQQVVGCV AIVGGVVFRL LLSYGFGLDY IRDYTTTIST LEPVYNELLS ALGLADKGVE
     QTLKRSMAPR PYMNYISAAR AALDDELLIV EKRTTGPGTH SAARESLLTW FDFRARDRWG
     VRIPDRDTTS TQVLAPITAS LYSDDDLIAA ASKLSFDALD APPTQIIDDP SFAPYMLATV
     VLDAFNAILT SRFSADSVSQ ALRVLSWARD YGAGSIANVD GYRTKLTAII ASVSPFLQKD
     APTPTMAHAN NLEALLGELH SVVVAAIALI PERARMPVPE RPSVKTSTFL AGLFLTAVYK
     RLETLVGHTA ELTNNILGTA SGIVSSIVTL NRFFNCRIMP VMGHYAVLIY PQSAQSAPFG
     RWRLVDVVDA VGSIYNEVSD LRADLRADVV TLKGDITSAA EALQECEALA VKTEGTRFGK
     LFNSLLTRHT QLARAQRGLA IRAGKLLGGS EAPGLKHVNT FLQRWGAISV MYQKATSGST
     PEVNITSLAN TLRHVWDEVQ QERKATPPSR KFSNRDLGLA VERLMGGYPE VLDDDSNSTA
     LTPKFNVDSW NSVNMDALRK RVTMPANIDS IRGNDSLATR EYLKKEDLLA EIDAIFNNTK