ID   ITP_EHV2                Reviewed;         965 AA.
AC   Q66665;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 65.
DE   RecName: Full=Inner tegument protein {ECO:0000255|HAMAP-Rule:MF_04043};
GN   Name=63;
OS   Equine herpesvirus 2 (strain 86/87) (EHV-2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Percavirus.
OX   NCBI_TaxID=82831;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7783207; DOI=10.1006/jmbi.1995.0314;
RA   Telford E.A.R., Watson M.S., Aird H.C., Perry J., Davison A.J.;
RT   "The DNA sequence of equine herpesvirus 2.";
RL   J. Mol. Biol. 249:520-528(1995).
CC   -!- FUNCTION: Plays an essential role in cytoplasmic secondary envelopment
CC       during viral egress. Interacts with the capsid via the large tegument
CC       protein/LTP and participates in its transport to the host trans-Golgi
CC       network (TGN) where secondary envelopment occurs. Modulates
CC       tegumentation and capsid accumulation at the viral assembly complex.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with the large tegument protein/LTP
CC       (via N-terminus). {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04043}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04043}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04043}. Host Golgi apparatus, host
CC       trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SIMILARITY: Belongs to the herpesviridae inner tegument protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
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DR   EMBL; U20824; AAC13851.1; -; Genomic_DNA.
DR   PIR; S55658; S55658.
DR   RefSeq; NP_042660.1; NC_001650.2.
DR   GeneID; 1461054; -.
DR   KEGG; vg:1461054; -.
DR   Proteomes; UP000007083; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039701; P:microtubule-dependent intracellular transport of viral material towards cell periphery; IEA:UniProtKB-UniRule.
DR   GO; GO:0019068; P:virion assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04043; HSV_ITP; 1.
DR   InterPro; IPR007611; Herpes_U30.
DR   InterPro; IPR034738; HSV_ITP.
DR   Pfam; PF04523; Herpes_U30; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Reference proteome;
KW   Virion; Virion tegument.
FT   CHAIN           1..965
FT                   /note="Inner tegument protein"
FT                   /id="PRO_0000406040"
FT   REGION          489..965
FT                   /note="Interaction with large tegument protein"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04043"
SQ   SEQUENCE   965 AA;  106096 MW;  4DCEE61E977B4C54 CRC64;
     MNPQASLDRL AQRLSDAENL FKKVRVLVDL ESAPLSLRSL SDPVRIASFL NTLSDRGNEY
     LAFIRHRPAF YLLRVASFGE QVPLGAGDLQ GAVGLLTSAV RAFKDLKPPP EGTPAPANNL
     LENSNILTRL SQFIAHLRSL DLSQPVTFTP PASLVTLRCI EEITFSFWHA HWTAPPEVSL
     PKPNPQSKLE RWLALSYAAA LGAARDNAPK HRRELRALAK SLLTTERDLF APVSVVTETS
     LTLPLAKERA REIFSMVDDA LPGDAAARGA PVLGFRDADL NAASPEYVFL YEHVFEALLH
     DQTYGCARRT VEAFLERCLK FLVNLGSYVQ TACSNKSHLS PPEIEGVRAA FHACGLTREA
     CHTFSTMLAI APAGGAASRL KHLHATVQHL EQITVFGRHF YECLRRCSPT SISHRLVREV
     LRTAQVEQNS ATPWTAGAAE GSALGWPVHS YLRIFLPRPP EDDLAATFKA ASESNFMKSL
     IGVSVKRDWD LNKFYVLSKK APGGGGNGEG GSGGGNGGAG TVSRKQVRKF CEGLNPGDAD
     YALEVVQSKY FAPEFARAVL LPELEAMLRG RVRRHVMLFR LRWLVLFAFE DAAGLAHIRR
     PLTLAYFQLT EIFGQGGVGS GAGAAGGGDG GALGNLLDHF HEAWTAAREL VPEAGGEVPH
     ELLTNIYRSL HAPAAREQLA AAAAFLKEIK PLVEGTWNMM RIASVLCHAR YNYLSASGHL
     RVPFGEKPGY VDVPVPVFKE TVKIMESSLH ETLVILSQAC QDLQRFYAAC LGILDQNQFL
     ATHPVQLDLS EPDFQAVKET LLGCLRRYRE VASLAAGSCC FSLTRHFGAL FDPPLITEAV
     VRKVLEFSEE RDTTDAFIES LQQPIAKVEE EDWDDAPPKH ALNDYDLTAL REINESFPLP
     KQHGNNPPET TPSIKLSYTD SVNVSQITLD WEKFLRTSYI PQDAITSEFS HITVKKLEQS
     ITGSF