ID   ITP_GAHVM               Reviewed;        1046 AA.
AC   Q9E6N2;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   23-FEB-2022, entry version 57.
DE   RecName: Full=Inner tegument protein {ECO:0000255|HAMAP-Rule:MF_04043};
GN   Name=MDV050;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
CC   -!- FUNCTION: Plays an essential role in cytoplasmic secondary envelopment
CC       during viral egress. Interacts with the capsid via the large tegument
CC       protein/LTP and participates in its transport to the host trans-Golgi
CC       network (TGN) where secondary envelopment occurs. Modulates
CC       tegumentation and capsid accumulation at the viral assembly complex.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with the large tegument protein/LTP
CC       (via N-terminus). {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04043}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04043}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04043}. Host Golgi apparatus, host
CC       trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SIMILARITY: Belongs to the herpesviridae inner tegument protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
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DR   EMBL; AF243438; AAG14230.1; -; Genomic_DNA.
DR   RefSeq; YP_001033966.1; NC_002229.3.
DR   SMR; Q9E6N2; -.
DR   GeneID; 4811511; -.
DR   KEGG; vg:4811511; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039701; P:microtubule-dependent intracellular transport of viral material towards cell periphery; IEA:UniProtKB-UniRule.
DR   GO; GO:0019068; P:virion assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04043; HSV_ITP; 1.
DR   InterPro; IPR005655; Herpes_UL37.
DR   InterPro; IPR034738; HSV_ITP.
DR   Pfam; PF03970; Herpes_UL37_1; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Reference proteome;
KW   Virion; Virion tegument.
FT   CHAIN           1..1046
FT                   /note="Inner tegument protein"
FT                   /id="PRO_0000406516"
FT   REGION          543..1046
FT                   /note="Interaction with large tegument protein"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04043"
SQ   SEQUENCE   1046 AA;  116523 MW;  365E8423D22414FC CRC64;
     MSAVTTDEIW PLKVLLDTLR SLSSRTSPTE PWGATATAEA RAAIGSFFLA SGTMSILQVE
     LTWRDTFSAI LEVYKQTRSP EASMLAQNFV GLILWRISVR WDKTSWQENS HRLRRLVAEM
     TGEEAISWLS RNNLRISAPF GPSVMWPLIS EWFAVFEDAA NHAFTYTPEH LLSEREFSFN
     VGDLAASLAH KRFELIYDFP FVQEGIRLVS IASGWIAPFV IMYRCTTNRV FTPLTRILFT
     IALVDQYFRG LHAPQPFQIK DRFAEDVGAL GSKELIPALE ANSTKRTSYE VRASAAIAYE
     SPFVHTIQPG MAADKLRNGS DIIMSDTSLT EDSLAIHLSA VLRLISDIGL EEDNGAIDAA
     KAKLSNSARR AWDAIQYSSS PKQLLEALIE RGFVRQVCRA YESALKTYFT RNYGSVDEGD
     IFDDVQQVVG CVAVIGNVVF GLIESYGPGM TYLSNYMENC VISESDSHFI EALGLERAII
     SQIIGRCIPP IPHEDYIKAA RAVLVAEMDH VASKSEAVGF RQSIRSAKES LMLWFDNRAN
     EIWGIVPPDE SNVLNLDANL PNSDYSNVDS NVEQDEFDGE RESEMIRLAS TIRYPEPMPI
     TPESTTPHFL KYIIATVCLD ALTSVTTAIF STPRLGTALK VLTWARDYGM PYLDSFINHR
     GKLNALISAI IPFTQDISNA PTTDDALNIE MLLGELYDVI SVAISMLPQE ARPFLPPRPD
     PSNSNVLISM HGTALHLQLN YLAERTFDCV EHLSNKSKQL VVFASIFKDF FTCKFVSGIS
     GGTVKLYHHS ELHSSLGTWK IFDVMTAIRE LYDSANNIIA DIRLDSMKLR TIIEETGKQL
     LLCDDIMEQA NALGQDAVKL FSVLGADFAG LTRLQNSLDL HIRKLTSCNT PPGMQDICWL
     LGRWSILSEI NSTYRDRSSH ELVSAIENVG GVLQDMMDHD LASIGTDDKS VAGEIEFAVE
     SVMRDYPVIT EDDTTLVVTL SSRHNLTHRD EINFCTLDIE TIAPDDVDLT SFARDFITKQ
     RVTADALVNI IDTVFNTGRR ANGDNA