ITP_HCMVA
ID ITP_HCMVA Reviewed; 983 AA.
AC P16784; Q7M6N8;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 2.
DT 23-FEB-2022, entry version 69.
DE RecName: Full=Inner tegument protein {ECO:0000255|HAMAP-Rule:MF_04043};
GN Name=UL47;
OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX NCBI_TaxID=10360;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT "Analysis of the protein-coding content of the sequence of human
RT cytomegalovirus strain AD169.";
RL Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN [2]
RP GENOME REANNOTATION.
RX PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RT "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT cytomegalovirus genome.";
RL J. Gen. Virol. 84:17-28(2003).
RN [3]
RP ERRATUM OF PUBMED:12533697.
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RL J. Gen. Virol. 84:1053-1053(2003).
RN [4]
RP IDENTIFICATION.
RX PubMed=15452216; DOI=10.1128/jvi.78.20.10960-10966.2004;
RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA Shenk T., Smith R.D., Nelson J.A.;
RT "Identification of proteins in human cytomegalovirus (HCMV) particles: the
RT HCMV proteome.";
RL J. Virol. 78:10960-10966(2004).
RN [5]
RP ERRATUM OF PUBMED:15452216.
RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA Shenk T., Smith R.D., Nelson J.A.;
RL J. Virol. 78:13395-13395(2004).
CC -!- FUNCTION: Plays an essential role in cytoplasmic secondary envelopment
CC during viral egress. Interacts with the capsid via the large tegument
CC protein/LTP and participates in its transport to the host trans-Golgi
CC network (TGN) where secondary envelopment occurs. Modulates
CC tegumentation and capsid accumulation at the viral assembly complex.
CC {ECO:0000255|HAMAP-Rule:MF_04043}.
CC -!- SUBUNIT: Interacts (via C-terminus) with the large tegument protein/LTP
CC (via N-terminus). {ECO:0000255|HAMAP-Rule:MF_04043}.
CC -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC Rule:MF_04043}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04043}. Host
CC nucleus {ECO:0000255|HAMAP-Rule:MF_04043}. Host Golgi apparatus, host
CC trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04043}.
CC -!- SIMILARITY: Belongs to the herpesviridae inner tegument protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04043}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA35406.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X17403; CAA35406.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK000394; DAA00150.1; -; Genomic_DNA.
DR PIR; S09810; S09810.
DR SMR; P16784; -.
DR PRIDE; P16784; -.
DR Proteomes; UP000008991; Genome.
DR Proteomes; UP000008992; Genome.
DR GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR GO; GO:0039701; P:microtubule-dependent intracellular transport of viral material towards cell periphery; IEA:UniProtKB-UniRule.
DR GO; GO:0019068; P:virion assembly; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04043; HSV_ITP; 1.
DR InterPro; IPR007611; Herpes_U30.
DR InterPro; IPR034738; HSV_ITP.
DR Pfam; PF04523; Herpes_U30; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host Golgi apparatus; Host nucleus; Reference proteome;
KW Virion; Virion tegument.
FT CHAIN 1..983
FT /note="Inner tegument protein"
FT /id="PRO_0000116053"
FT REGION 474..983
FT /note="Interaction with large tegument protein"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04043"
FT REGION 901..932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 983 AA; 110092 MW; B95BA9D3AEA1243E CRC64;
MMARRTVDFK KLIEQLRARA TDKAEALNTV SQLEIGAVDA QDVTASAVRA FVGALPSSGY
HFGFVRQNVV FYLLSHATVQ TARDPLYAAE QLHEQLDRFL RHQHDGGGDE DRLPFYHNGA
TLTAFQKLLQ TLREIQTVIA EQSGGTAAAA DLIASNNAST ERRGKKGGSS SGGQQPLVRR
VITQLETAAT EARPYVNCRA VAELLDLTYQ RLIYWACTLM PYVLFRRDTD TELDTVLLMH
FFYTHYRSVN GDLAVEFQNY VKNSVRHMSS FVSSDIDGDQ KPGAEHMRDV SYKLFVGNLQ
ARDASGLMFP IISTRISTVN LYLSPERMFF HPGLISRLLS EEVSPRANLD AYARVCDRVL
EDHLHTPRRV QRLLDLTQMV MRLVELGFNH DTCAAYAQMA LIQPASQKSS LFVSEIREKL
IQIIYNFYTF FMCLYVYSPT FLFDHRRRLI LEQHRSTLIG SKEELQHVWS NVTLNVNTHF
AVQYTEEDFE AHTKGATEAE REYLYRDLHS KWGVHLFTLR PSRGAAGAAS PLPPLDGVTR
SDILRECALV NLNEGRVNYA SLLAFSHHPE FPSIFAQLVV VTEFSEIFGI PQGLFQAVGS
PRLFALIQLC RVLLPEQVTL YQNLVSIYNL TTFVKHIDAA VFKTVRDCVF DIATTLEHLS
GVPVTPNVDL LAELMARSVA HNLYTTVNPL IEDVMRSSAG SLRNYLRHTR LCFGLARGRA
RLSEDGVTVY VEVQGQYGLR VPTTRFVEQL RELVRRDRLL AENLRGLNER LLSVRVRVRQ
ISSDTEEVSR HAKGHRTVAQ MSKALKKTAS KIKVLETRVT LALEQAQRSN GAVVTAVQRA
LAVFDVLSRE NLERRGAQLC LTEATSLLHR HRALAPMTWP AGTGVAAAAE ADRALREFLE
APWESAPQPP RLRMTPDTDH EESTAGATSV PEVLGARYEP AHLAASDLLN WYIVPVSQAQ
QDILSSIDPP AGSTSVSLPP ASP
