ID   ITP_HCMVM               Reviewed;         983 AA.
AC   Q6SW85; D2K3L4;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 59.
DE   RecName: Full=Inner tegument protein {ECO:0000255|HAMAP-Rule:MF_04043};
GN   Name=UL47;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Plays an essential role in cytoplasmic secondary envelopment
CC       during viral egress. Interacts with the capsid via the large tegument
CC       protein/LTP and participates in its transport to the host trans-Golgi
CC       network (TGN) where secondary envelopment occurs. Modulates
CC       tegumentation and capsid accumulation at the viral assembly complex.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with the large tegument protein/LTP
CC       (via N-terminus). {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04043}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04043}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04043}. Host Golgi apparatus, host
CC       trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SIMILARITY: Belongs to the herpesviridae inner tegument protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
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DR   EMBL; AY446894; AAR31611.1; -; Genomic_DNA.
DR   RefSeq; YP_081505.1; NC_006273.2.
DR   SMR; Q6SW85; -.
DR   BioGRID; 1678074; 1.
DR   PRIDE; Q6SW85; -.
DR   DNASU; 3077521; -.
DR   GeneID; 3077521; -.
DR   KEGG; vg:3077521; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0072517; C:host cell viral assembly compartment; TAS:Reactome.
DR   GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR   GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039701; P:microtubule-dependent intracellular transport of viral material towards cell periphery; IEA:UniProtKB-UniRule.
DR   GO; GO:0019068; P:virion assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04043; HSV_ITP; 1.
DR   InterPro; IPR007611; Herpes_U30.
DR   InterPro; IPR034738; HSV_ITP.
DR   Pfam; PF04523; Herpes_U30; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Reference proteome;
KW   Virion; Virion tegument.
FT   CHAIN           1..983
FT                   /note="Inner tegument protein"
FT                   /id="PRO_0000418296"
FT   REGION          474..983
FT                   /note="Interaction with large tegument protein"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04043"
FT   REGION          902..932
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   983 AA;  110024 MW;  8227D02C0056A636 CRC64;
     MMARRTVDFK KLIEQLRARA TDKAEALNTV SQLEIGAVDA QDVTASAVRA FVGALPSSGY
     HFGFVRQNVV FYLLSHATVQ TARDPLYAAE QLHEQLDRFL RHQHDGGGDE DRLPFYHNGA
     TLTAFQKLLQ TLREIQTVIA EQSGGTAAAA DLIASNNAST ERRGKKGGSS SGGQQPLVRR
     VITQLETAAT EARPYVNCRA VAELLDLTYQ RLIYWACTLM PYVLFRRDTD TELDTVLLMH
     FFYTHYRSVN GDLAVEFQNY VKNSVRHMSS FVSSDIDGDQ KPGAEHMRDV SYKLFVGNLQ
     ARDASGLMFP IISTRISTVN LYLSPERMFF HPGLISRLLS EEVSPRANLD AYARVCDRVL
     EDHLHTPRRV QRLLDLTQMV MRLVELGFNH DTCAAYAQMA LIQPASQKSS LFVSEIREKL
     IQIIYNFYTF FMCLYVYSPT FLFDHRRRLI LEQHRSTLIG SKEELQHVWS NVTLNVNTHF
     AVQYTEEDFE AHTKGATEAE REYLYRDLHS KWGVHLFTLR PSRGAAGAAS PLPPLDGVTR
     SDILRECALV NLNEGRVNYA SLLAFSHHPE FPSIFAQLVV VTEFSEIFGI PQGLFQAVGS
     PRLFALIQLC RVLLPEQVTL YQNLVSIYNL TTFVKHIDAA VFKTVRDCVF DIATTLEHLS
     GVPVTPNVDL LAELMARSVA HNLYTTVNPL IEDVMRSSAG SLRNYLRHTR LCFGLARGRA
     RLSEDGVTVY VEVQGQYGLR VPTTRFVEQL RELVRRDRLL AENLRGLNER LLSVRVRVRQ
     ISSDTEEVSR HAKGHRTVAQ MSKALKKTAS KIKMLETRVT LALEQAQRSN GAVVTAVQRA
     LAVFDVLSRE NLERRGAQLC LTEATSLLHR HRALAPMTWP AGTGVAAAAE ADGALREFLE
     APWESAPQPP RLRMTPDTDH EESTAGATSV PEVLGARYEP AHLAASDLLN WYIVPVSQAQ
     QDILSSIDPP AGSTSVSLPP ASP