位置:首页 > 蛋白库 > ITP_HHV6U
ITP_HHV6U
ID   ITP_HHV6U               Reviewed;        1082 AA.
AC   P52437; Q69054;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   23-FEB-2022, entry version 59.
DE   RecName: Full=Inner tegument protein {ECO:0000255|HAMAP-Rule:MF_04043};
GN   Name=U30; Synonyms=P2RF1;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8289364; DOI=10.1128/jvi.68.2.597-610.1994;
RA   Nicholas J., Martin M.E.D.;
RT   "Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome
RT   of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene
RT   homologs and transactivating functions.";
RL   J. Virol. 68:597-610(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- FUNCTION: Plays an essential role in cytoplasmic secondary envelopment
CC       during viral egress. Interacts with the capsid via the large tegument
CC       protein/LTP and participates in its transport to the host trans-Golgi
CC       network (TGN) where secondary envelopment occurs. Modulates
CC       tegumentation and capsid accumulation at the viral assembly complex.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with the large tegument protein/LTP
CC       (via N-terminus). {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04043}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04043}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04043}. Host Golgi apparatus, host
CC       trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SIMILARITY: Belongs to the herpesviridae inner tegument protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA16738.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L25528; AAA16738.1; ALT_INIT; Genomic_DNA.
DR   EMBL; X83413; CAA58410.1; -; Genomic_DNA.
DR   PIR; T09325; T09325.
DR   RefSeq; NP_042923.2; NC_001664.2.
DR   SMR; P52437; -.
DR   PRIDE; P52437; -.
DR   GeneID; 1487908; -.
DR   KEGG; vg:1487908; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039701; P:microtubule-dependent intracellular transport of viral material towards cell periphery; IEA:UniProtKB-UniRule.
DR   GO; GO:0019068; P:virion assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04043; HSV_ITP; 1.
DR   InterPro; IPR007611; Herpes_U30.
DR   InterPro; IPR034738; HSV_ITP.
DR   Pfam; PF04523; Herpes_U30; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Reference proteome;
KW   Virion; Virion tegument.
FT   CHAIN           1..1082
FT                   /note="Inner tegument protein"
FT                   /id="PRO_0000116048"
FT   REGION          604..1082
FT                   /note="Interaction with large tegument protein"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04043"
SQ   SEQUENCE   1082 AA;  124058 MW;  C595695408F1A989 CRC64;
     MTHDNRQLLP QETKLVTPNK DTLSSRYLHV LIIDNTLSTI EFVYMAVKAV LTQVDTLNAL
     EQRKNRPTNR ILGLSTSVSK RYINIPKFSS SGASNSQGVK TLAAIRKFCL PDKNCFRNFL
     SFSTTLFKVP SSIDIYFLFF TASTVSTMAA RALDLEFILS SLKNSTSPES LLAATAKIEL
     LSLAADSVTH NRVIAFINRL TPKKYHFDLI RQYAVFYFLN STTLTSENKL LSAELLYEEL
     SQIPSSSSSG TELENLNNAE VLYVFDRILN SIKMLKNELS SPIGKLRAQP AANDPGTDKT
     IKYSKIQSII QKINSFTHEN SLLANCRAVV ELIDDLYRKL YSWFLHVLTF EDIQFPGDTF
     LDRLLKMDYC FTYYPSSNRH LIDLFEKTLD NQTFTNLDKF FDTSGNSPEL LYQKTFSLKI
     FSKNLTAQDN GLYIYPLLKT DLSILDFLGT ENILFHRGLI YHILHQKTIP QERENDLNKI
     NQFFATVIQQ VIETKSSCLP ASLSQLLDTI FHFNRIGLNM ETCRTYIEIL SNHMATPDTQ
     PIINTFTINL THIVFTAHVF FICMENFSPT FIFYNRKKLI LEQQRAILII ERNDYSTLWK
     QISDHIECLF NVSLSESFFK EYTKGGNEDQ KQFLYKNLFE KWGNVFFPFT YSVSTSNNST
     AHHITTLELR DICKEVYQSD SPDAYESLLP YSTHPSFKTL FVKIYVIPMV SHITNLTFDK
     LQSDCRLLTL IHACKLLLPS QHLLLHYMAW LYAFSINVDH IDLGTFTVIK SVIFKIADHI
     NVMTHTIYSP ETNLLVSILL NAYTNYLQKY VNPWIKQTIT ANFSLIQTYI TFTKQCASIL
     ATKCNINLDN LFIYITIGTD KIVTTSFCSF IATCRNLVRQ HEEFEKSLQT IQISEITLTG
     MLRNIITSVS SSKELLTNEA LQKFIDTVQR ISQHVNETYH SISVNLEKCK TSNDILIESL
     KKIIYIVDVL SSNAILNTSL ASRCLEAANL AVSNNSFTIL EIKKDAVAVF KPFITQLFES
     MKPTTSLHKK LMSTQKLTTD HIPFLDTFDD RYNLVRHVER QLNWYAAHAE AAQQDLITPL
     KF
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024