ITP_HHV6U
ID ITP_HHV6U Reviewed; 1082 AA.
AC P52437; Q69054;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 23-FEB-2022, entry version 59.
DE RecName: Full=Inner tegument protein {ECO:0000255|HAMAP-Rule:MF_04043};
GN Name=U30; Synonyms=P2RF1;
OS Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS lymphotropic virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX NCBI_TaxID=10370;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8289364; DOI=10.1128/jvi.68.2.597-610.1994;
RA Nicholas J., Martin M.E.D.;
RT "Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome
RT of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene
RT homologs and transactivating functions.";
RL J. Virol. 68:597-610(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT genome evolution.";
RL Virology 209:29-51(1995).
CC -!- FUNCTION: Plays an essential role in cytoplasmic secondary envelopment
CC during viral egress. Interacts with the capsid via the large tegument
CC protein/LTP and participates in its transport to the host trans-Golgi
CC network (TGN) where secondary envelopment occurs. Modulates
CC tegumentation and capsid accumulation at the viral assembly complex.
CC {ECO:0000255|HAMAP-Rule:MF_04043}.
CC -!- SUBUNIT: Interacts (via C-terminus) with the large tegument protein/LTP
CC (via N-terminus). {ECO:0000255|HAMAP-Rule:MF_04043}.
CC -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC Rule:MF_04043}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04043}. Host
CC nucleus {ECO:0000255|HAMAP-Rule:MF_04043}. Host Golgi apparatus, host
CC trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04043}.
CC -!- SIMILARITY: Belongs to the herpesviridae inner tegument protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04043}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA16738.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L25528; AAA16738.1; ALT_INIT; Genomic_DNA.
DR EMBL; X83413; CAA58410.1; -; Genomic_DNA.
DR PIR; T09325; T09325.
DR RefSeq; NP_042923.2; NC_001664.2.
DR SMR; P52437; -.
DR PRIDE; P52437; -.
DR GeneID; 1487908; -.
DR KEGG; vg:1487908; -.
DR Proteomes; UP000009295; Genome.
DR GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR GO; GO:0039701; P:microtubule-dependent intracellular transport of viral material towards cell periphery; IEA:UniProtKB-UniRule.
DR GO; GO:0019068; P:virion assembly; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04043; HSV_ITP; 1.
DR InterPro; IPR007611; Herpes_U30.
DR InterPro; IPR034738; HSV_ITP.
DR Pfam; PF04523; Herpes_U30; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host Golgi apparatus; Host nucleus; Reference proteome;
KW Virion; Virion tegument.
FT CHAIN 1..1082
FT /note="Inner tegument protein"
FT /id="PRO_0000116048"
FT REGION 604..1082
FT /note="Interaction with large tegument protein"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04043"
SQ SEQUENCE 1082 AA; 124058 MW; C595695408F1A989 CRC64;
MTHDNRQLLP QETKLVTPNK DTLSSRYLHV LIIDNTLSTI EFVYMAVKAV LTQVDTLNAL
EQRKNRPTNR ILGLSTSVSK RYINIPKFSS SGASNSQGVK TLAAIRKFCL PDKNCFRNFL
SFSTTLFKVP SSIDIYFLFF TASTVSTMAA RALDLEFILS SLKNSTSPES LLAATAKIEL
LSLAADSVTH NRVIAFINRL TPKKYHFDLI RQYAVFYFLN STTLTSENKL LSAELLYEEL
SQIPSSSSSG TELENLNNAE VLYVFDRILN SIKMLKNELS SPIGKLRAQP AANDPGTDKT
IKYSKIQSII QKINSFTHEN SLLANCRAVV ELIDDLYRKL YSWFLHVLTF EDIQFPGDTF
LDRLLKMDYC FTYYPSSNRH LIDLFEKTLD NQTFTNLDKF FDTSGNSPEL LYQKTFSLKI
FSKNLTAQDN GLYIYPLLKT DLSILDFLGT ENILFHRGLI YHILHQKTIP QERENDLNKI
NQFFATVIQQ VIETKSSCLP ASLSQLLDTI FHFNRIGLNM ETCRTYIEIL SNHMATPDTQ
PIINTFTINL THIVFTAHVF FICMENFSPT FIFYNRKKLI LEQQRAILII ERNDYSTLWK
QISDHIECLF NVSLSESFFK EYTKGGNEDQ KQFLYKNLFE KWGNVFFPFT YSVSTSNNST
AHHITTLELR DICKEVYQSD SPDAYESLLP YSTHPSFKTL FVKIYVIPMV SHITNLTFDK
LQSDCRLLTL IHACKLLLPS QHLLLHYMAW LYAFSINVDH IDLGTFTVIK SVIFKIADHI
NVMTHTIYSP ETNLLVSILL NAYTNYLQKY VNPWIKQTIT ANFSLIQTYI TFTKQCASIL
ATKCNINLDN LFIYITIGTD KIVTTSFCSF IATCRNLVRQ HEEFEKSLQT IQISEITLTG
MLRNIITSVS SSKELLTNEA LQKFIDTVQR ISQHVNETYH SISVNLEKCK TSNDILIESL
KKIIYIVDVL SSNAILNTSL ASRCLEAANL AVSNNSFTIL EIKKDAVAVF KPFITQLFES
MKPTTSLHKK LMSTQKLTTD HIPFLDTFDD RYNLVRHVER QLNWYAAHAE AAQQDLITPL
KF