ID   ITP_HHV6Z               Reviewed;        1082 AA.
AC   Q9QJ38;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   23-FEB-2022, entry version 51.
DE   RecName: Full=Inner tegument protein {ECO:0000255|HAMAP-Rule:MF_04043};
GN   Name=U30;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
CC   -!- FUNCTION: Plays an essential role in cytoplasmic secondary envelopment
CC       during viral egress. Interacts with the capsid via the large tegument
CC       protein/LTP and participates in its transport to the host trans-Golgi
CC       network (TGN) where secondary envelopment occurs. Modulates
CC       tegumentation and capsid accumulation at the viral assembly complex.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with the large tegument protein/LTP
CC       (via N-terminus). {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04043}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04043}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04043}. Host Golgi apparatus, host
CC       trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SIMILARITY: Belongs to the herpesviridae inner tegument protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
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DR   EMBL; AF157706; AAD49644.1; -; Genomic_DNA.
DR   RefSeq; NP_050211.1; NC_000898.1.
DR   PRIDE; Q9QJ38; -.
DR   GeneID; 1497032; -.
DR   KEGG; vg:1497032; -.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039701; P:microtubule-dependent intracellular transport of viral material towards cell periphery; IEA:UniProtKB-UniRule.
DR   GO; GO:0019068; P:virion assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04043; HSV_ITP; 1.
DR   InterPro; IPR007611; Herpes_U30.
DR   InterPro; IPR034738; HSV_ITP.
DR   Pfam; PF04523; Herpes_U30; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Reference proteome;
KW   Virion; Virion tegument.
FT   CHAIN           1..1082
FT                   /note="Inner tegument protein"
FT                   /id="PRO_0000408445"
FT   REGION          604..1082
FT                   /note="Interaction with large tegument protein"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04043"
SQ   SEQUENCE   1082 AA;  124293 MW;  0E1E2B128872CF7A CRC64;
     MTHDNRQLLP QETKLVTPNK DTLSSRYLHV LIIDNTLSTI EFVYMVVKAV LTQADTLKAF
     EQRKNRPTNR ILGLSTSVSK RYINIPKFSS SGANNSQGVK TLAAIRKFSL PDKNCFRNFL
     SFSTTLFKVP ASIDIYFLFF TASTVSTMAA RALDLEFILS SLKNSTSPES LLAATAKIEI
     LSLAADSVTH NRVIAFINRL PPKKYHFDLI REYTVFYFLN STTLTSENKL LSAELLHEEL
     SQIRSSSSPG TELENLNNAE VLYVFDRILN SIKMLKNELS SPIGKLRVQP AANDPGTDKT
     IKYSKIQSII QKVHSFTREN SLLANCRAVV ELIDDLYRKL YSWFLHILTF EDIQFPGDTF
     LDRLLKMDYC FTYYPSSNRH LIDLFEKTLD NQTSTDIDKF FDTSGNSPEL LYQKTFSLKI
     FSKNLTAQDN GLYIYPLLKT DLSILDFLGT ENILFHRGLI YHILHQKTIP QERENDLNKI
     NQFFATVIQQ VIETRSSCLP ASLSRLLDTI FHFNRIGLNI ETCRIYVEIL SNHMATPDTQ
     PIINTFTINL IHIVFTAHVF FICMENFSPT FLFYNRKKLI LEQQRAILII ERNEYSTLWK
     QISDHIDCLF NISLSESFFK EYTKGGNEEH KQFLYKNLFE KWGDVFFPFT YSVTTSKNST
     AHHITTLELR AICKEVYQSD SPEAYESLLP YSTHPAFKTL FIKIYVIPMV TYITNLTFDK
     LQSDYRLITL IHACKLLLPS QHLLLHYMVW LYAFSINVDH IDLGTFTVIK SVIFKIADHI
     NVMTHTIYSP ETNLLVSILL NAYTDYLQKY VNPWIKQTIT ANFSLLQTYI TFTKQCASIL
     ATKCNINLDN LFISMTIGTD KIVTTSFCSF IATCRNLVRQ HEEFKKSLKT IETSKTTLTN
     MLLNIITSVS SSKELLTNEA LQKFIDTVQR ISQHVNETYQ LISVNLEKCK ISNDILIESL
     KKTISIVDVL SSDAILNTSL TSRCLEAATL AVSNNSFTIL EIKKDAVAVF KPFITQLFES
     MKPTTSLYKK LMATQKLTTD RIPFLDIFDD RYNLVRHVER QLNWYAAYAE AAQQDLIAPL
     TF