ID   ITP_HHV7J               Reviewed;         938 AA.
AC   P52438;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   23-FEB-2022, entry version 69.
DE   RecName: Full=Inner tegument protein {ECO:0000255|HAMAP-Rule:MF_04043};
GN   Name=U30;
OS   Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=57278;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8709220; DOI=10.1128/jvi.70.9.5975-5989.1996;
RA   Nicholas J.;
RT   "Determination and analysis of the complete nucleotide sequence of human
RT   herpesvirus.";
RL   J. Virol. 70:5975-5989(1996).
CC   -!- FUNCTION: Plays an essential role in cytoplasmic secondary envelopment
CC       during viral egress. Interacts with the capsid via the large tegument
CC       protein/LTP and participates in its transport to the host trans-Golgi
CC       network (TGN) where secondary envelopment occurs. Modulates
CC       tegumentation and capsid accumulation at the viral assembly complex.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with the large tegument protein/LTP
CC       (via N-terminus). {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04043}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04043}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04043}. Host Golgi apparatus, host
CC       trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SIMILARITY: Belongs to the herpesviridae inner tegument protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
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DR   EMBL; U43400; AAC54692.1; -; Genomic_DNA.
DR   PIR; T41932; T41932.
DR   RefSeq; YP_073770.1; NC_001716.2.
DR   SMR; P52438; -.
DR   PRIDE; P52438; -.
DR   GeneID; 3289488; -.
DR   KEGG; vg:3289488; -.
DR   Proteomes; UP000009246; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039701; P:microtubule-dependent intracellular transport of viral material towards cell periphery; IEA:UniProtKB-UniRule.
DR   GO; GO:0019068; P:virion assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04043; HSV_ITP; 1.
DR   InterPro; IPR007611; Herpes_U30.
DR   InterPro; IPR034738; HSV_ITP.
DR   Pfam; PF04523; Herpes_U30; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Reference proteome;
KW   Virion; Virion tegument.
FT   CHAIN           1..938
FT                   /note="Inner tegument protein"
FT                   /id="PRO_0000116049"
FT   REGION          457..938
FT                   /note="Interaction with large tegument protein"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04043"
SQ   SEQUENCE   938 AA;  110171 MW;  F4E39A2BF0D32BC9 CRC64;
     MDCTNLQFES ILNLLKTDVS DNTFLTITAK IEIFSLAAES ITADKILSFA KLLPIHNYHF
     NFIKNHMVFY ILNYSTLGFA KRFSIAETLC RELKIFHRTF QSTSKLQNLN NAEVLYQFEK
     LIESIQVFKA ELASPIGKLL RQETMIYDKP TEKSVKYVII QQNLIKINNL IQDCESIKNC
     RLIAELIDEL YQKVYRWFMQ IFTYDDIIFP NDNFLDRLLK MDFCYTYYTA SNQHLLSLFE
     QTIDNQIFID PSPYFEINPV YSPELQFMST FSLKIFSKNI SAKNEDLYIY PLLKTNFSIL
     TFLSLENIFF HHGFIYHILH RTNITPTEEK KLGKINGFLN TVIQQVLIKK NNLQITFPEL
     LDKIYHLHRI GLNIETAQIF LQMLTTYKPA TTNNKLQTFF TNFSIIIFSA YIFFLCIELF
     SPTFIFHNKK KLILEKQKSI ILILGEQFSF IWKEVNEIVD LLFSSTVTET YFKFYSKGAD
     DYEKDFLYKD LMEKWGELFF PLTYSMTTPQ KYTDKHVSST VLKNLCDTAY QSKMETAYES
     LLPYITHPEF KFIFITHYVR PSLSLITNLT FEEIKDNRRL LILIFACKLL MPSNYLLSHY
     LLLLHAFTLQ IFKVDLGHFS IIHAITQKIF DNINSLTQTI FIPKTNFLVS LLLTAYTVHM
     QTYVNPWIQK TISENIALLK EYIDFTKKCS STLATTCYLN LENFAVNMYF GKNKVGSTSL
     SAFYRTCSKL IEESKLFKDR LQEIKVSKTL FIEMLQNVVK NITKFKDLVS NQTLQNFIII
     VERISSHANT TYQDVLNSID ECHFSNMQLI QSFKNIVYVI DVLNTKNIFN FSLASQLIEA
     KKLVKKQDTY NQLNVQDDFV TVLKSHLNNL FEKQKPTINI ERRFMLEGIP DIKQIPFLDV
     FDERYRLIPQ IEKYLHWYIA YSEAAQADLV EPLLLKLG