ID   ITP_HHV8P               Reviewed;         928 AA.
AC   F5HEU7;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 31.
DE   RecName: Full=Inner tegument protein {ECO:0000255|HAMAP-Rule:MF_04043};
GN   Name=ORF63;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
CC   -!- FUNCTION: Plays an essential role in cytoplasmic secondary envelopment
CC       during viral egress. Interacts with the capsid via the large tegument
CC       protein/LTP and participates in its transport to the host trans-Golgi
CC       network (TGN) where secondary envelopment occurs. Modulates
CC       tegumentation and capsid accumulation at the viral assembly complex.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with the large tegument protein/LTP
CC       (via N-terminus). {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04043}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04043}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04043}. Host Golgi apparatus, host
CC       trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SIMILARITY: Belongs to the herpesviridae inner tegument protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
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DR   EMBL; AF148805; ABD28918.1; -; Genomic_DNA.
DR   RefSeq; YP_001129420.1; NC_009333.1.
DR   BioGRID; 1776969; 1.
DR   PRIDE; F5HEU7; -.
DR   DNASU; 4961466; -.
DR   GeneID; 4961466; -.
DR   KEGG; vg:4961466; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039701; P:microtubule-dependent intracellular transport of viral material towards cell periphery; IEA:UniProtKB-UniRule.
DR   GO; GO:0019068; P:virion assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04043; HSV_ITP; 1.
DR   InterPro; IPR007611; Herpes_U30.
DR   InterPro; IPR034738; HSV_ITP.
DR   Pfam; PF04523; Herpes_U30; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Reference proteome;
KW   Virion; Virion tegument.
FT   CHAIN           1..928
FT                   /note="Inner tegument protein"
FT                   /id="PRO_0000423836"
FT   REGION          482..928
FT                   /note="Interaction with large tegument protein"
FT                   /evidence="ECO:0000250|UniProtKB:P10221"
SQ   SEQUENCE   928 AA;  103902 MW;  35342FC1B0BC3B22 CRC64;
     MDGTDALEKL TKGLSGGGGS LHQTKLLMEF QLRGLPVPAL LNSSTTEQFL NTVAQLPTDL
     SKFIRDYRVF ALVRAAYFLE PPSSIDPLEA ARALGRLVDI LSSQPPQNTA PAQPPTSDDT
     LNNCTLLKLL AHYADQIAGF KTPALPPVPP GIIGLFTCVE QMYHACFQKY WAAALPPMWI
     LTYDPPTSPL QDWLIVAYGN KEGLLLPSGI PSEEVLAKTL VTEHHELFVS RSNSTETAVT
     MPVSKERALA IYRVFAKGEV VAENTPILAF TDVELSTLKP HYLFIYDFII EALCKSYTYS
     CTQARLESFL SRGIDFMTDL GQYLDTATSG KQQLTHSQIK EIKYRLLSCG LSASACDVFR
     TVIMTLPYRP TPNLANLSTF MGMVHQLTMF GHYFYRCLGS YSPTGLAFTE LQKILTRASA
     EQTERNPWRH PGISDIPLRW KISRALAFFV PPAPINTLQR VYAALPSQLM RAIFEISVKT
     TWGGAVPANL ARDIDTGPNT QHISSTPPPT LKDVETYCQG LRVGDTEYDE DIVRSPLFAD
     AFTKSHLLPI LREVLENRLQ KNRALFQIRW LIIFAAEAAT GLIPARRPLA RAYFHIMDIL
     EERHSQDALY NLLDCIQELF THIRQAVPDA QCPHAFLQSL FVFQFRPFVL KHQQGVTLFL
     DGLQTSLPPV ISLANLGDKL CRLEFEYDSE GDFVRVPVAP PEQPPHVHLS HFKKTIQTIE
     QATREATVAM TTIAKPIYPA YIRLLQRLEY LNRLNHHILR IPFPQDALSE LQETYLAAFA
     RLTKLAADAA NTCSYSLTKY FGVLFQHQLV PTAIVKKLLH FDEAKDTTEA FLQSLAQPVV
     QGQRQGAAGG SGVLTQKELE LLNKINPQFT DAQANIPPSI KRSYSNKYDV PEVSVDWETY
     SRSAFEAPDD ELRFVPLTLA GLRKLFVE