ID   ITP_SHV21               Reviewed;         899 AA.
AC   Q01055;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   23-FEB-2022, entry version 62.
DE   RecName: Full=Inner tegument protein {ECO:0000255|HAMAP-Rule:MF_04043};
GN   Name=63; Synonyms=EERF1;
OS   Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=10383;
OH   NCBI_TaxID=9521; Saimiri sciureus (Common squirrel monkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1321287; DOI=10.1128/jvi.66.8.5047-5058.1992;
RA   Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B.,
RA   Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B.,
RA   Honess R.W.;
RT   "Primary structure of the herpesvirus saimiri genome.";
RL   J. Virol. 66:5047-5058(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1314457; DOI=10.1016/0042-6822(92)90759-i;
RA   Nicholas J., Cameron K.R., Coleman H., Newman C., Honess R.W.;
RT   "Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus
RT   saimiri (HVS) L-DNA: general conservation of genetic organization between
RT   HVS and Epstein-Barr virus.";
RL   Virology 188:296-310(1992).
CC   -!- FUNCTION: Plays an essential role in cytoplasmic secondary envelopment
CC       during viral egress. Interacts with the capsid via the large tegument
CC       protein/LTP and participates in its transport to the host trans-Golgi
CC       network (TGN) where secondary envelopment occurs. Modulates
CC       tegumentation and capsid accumulation at the viral assembly complex.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with the large tegument protein/LTP
CC       (via N-terminus). {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04043}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04043}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04043}. Host Golgi apparatus, host
CC       trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SIMILARITY: Belongs to the herpesviridae inner tegument protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
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DR   EMBL; X64346; CAA45686.1; -; Genomic_DNA.
DR   EMBL; M86409; AAA46139.1; -; Genomic_DNA.
DR   RefSeq; NP_040265.1; NC_001350.1.
DR   GeneID; 1682478; -.
DR   KEGG; vg:1682478; -.
DR   Proteomes; UP000000587; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039701; P:microtubule-dependent intracellular transport of viral material towards cell periphery; IEA:UniProtKB-UniRule.
DR   GO; GO:0019068; P:virion assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04043; HSV_ITP; 1.
DR   InterPro; IPR007611; Herpes_U30.
DR   InterPro; IPR034738; HSV_ITP.
DR   Pfam; PF04523; Herpes_U30; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Reference proteome;
KW   Virion; Virion tegument.
FT   CHAIN           1..899
FT                   /note="Inner tegument protein"
FT                   /id="PRO_0000116052"
FT   REGION          463..899
FT                   /note="Interaction with large tegument protein"
FT                   /evidence="ECO:0000250|UniProtKB:P10221"
SQ   SEQUENCE   899 AA;  103351 MW;  F1429B3770A2885E CRC64;
     MSVKPLTELT KNLEAASNEL LKTKVLMDME LNYLSIEQLE SAQNITDFLN ILKQTSSQYS
     TFIHQHFLFY LLKLSTFSTL NYDLESIKQY MNILNNVCDV ATTIHATSSS NFLNNQTVIN
     HIKQYITSNA TFTGLSEPIV PNNVISTFRC VEEVVHVCFQ CYWHFPFQAQ IPQIPNGALE
     KWLLTQHFKF LNLDYTAFNS LKDQATYLIT HEKHLFVPLS SSEYSLTLPL AKNQALNIYT
     SFTTNTITKS NVPVLAFSAK ELTDATPELF FLYDFIIEAL YHEHSYNVPQ NIIEQFISKN
     TQFMTDLCNT IQIKCSNKSL TSSEIRHIKE LLESCGLTEE CCHRLQTSVL ISNVSFTSNS
     WKGYETFISL ISQLVLFSDF FYKCLFYFSP TSIGHSKITE ILNTVSAIES ETLSHANKFS
     WKLANMLSFF IPKAPSKIIL ETYTHISPYL MKSAFSIWAK KTWNYTWLDA TSPHPTQTHT
     FKHAPVISQS EVQKYCENLQ LGTTEYDSRI VNSHLFAEEF ITHHIIPTLT AILQNKVQKN
     RALFQLRWLI VFASDEAKGL YRIRRPLGLL YFQIIEIFHD SNAAAAAILN VLDYLNEIQQ
     LIQYYVPTYT TPIKFIQELF SIKYKPQSTE LSKSIQKFIA ETETCVKDIL PFIQLGTNMC
     NTTYYHIENT YNINIQGQSP ARLDTKALTH AIKAIQGLTK ESWTTISQSY KELQTAYIQL
     ATILETIEKI SQHSIAIKVS NPNFIKLNNT FLQCFKKYNT IANLITNSHS FNLTRYFRQI
     FEPELIPITT VQKILNFNDE TDDPQPFLDS LSQPLYSHTN APKKSELTSE DFNRLLEFAN
     PVFETAPSSI KLHYSDTFNT PQVNINWKTY EHTTYIADSP AELQFTHLTS AILDAELSK