ID   ITP_VZVD                Reviewed;        1038 AA.
AC   P09277;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   23-FEB-2022, entry version 72.
DE   RecName: Full=Inner tegument protein {ECO:0000255|HAMAP-Rule:MF_04043};
GN   Name=21;
OS   Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10338;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=3018124; DOI=10.1099/0022-1317-67-9-1759;
RA   Davison A.J., Scott J.E.;
RT   "The complete DNA sequence of varicella-zoster virus.";
RL   J. Gen. Virol. 67:1759-1816(1986).
CC   -!- FUNCTION: Plays an essential role in cytoplasmic secondary envelopment
CC       during viral egress. Interacts with the capsid via the large tegument
CC       protein/LTP and participates in its transport to the host trans-Golgi
CC       network (TGN) where secondary envelopment occurs. Modulates
CC       tegumentation and capsid accumulation at the viral assembly complex.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with the large tegument protein/LTP
CC       (via N-terminus). {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000255|HAMAP-
CC       Rule:MF_04043}. Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04043}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04043}. Host Golgi apparatus, host
CC       trans-Golgi network {ECO:0000255|HAMAP-Rule:MF_04043}.
CC   -!- SIMILARITY: Belongs to the herpesviridae inner tegument protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04043}.
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DR   EMBL; X04370; CAA27904.1; -; Genomic_DNA.
DR   PIR; C27343; WZBE21.
DR   SMR; P09277; -.
DR   PRIDE; P09277; -.
DR   Proteomes; UP000002602; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0039701; P:microtubule-dependent intracellular transport of viral material towards cell periphery; IEA:UniProtKB-UniRule.
DR   GO; GO:0019068; P:virion assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04043; HSV_ITP; 1.
DR   InterPro; IPR005655; Herpes_UL37.
DR   InterPro; IPR034738; HSV_ITP.
DR   Pfam; PF03970; Herpes_UL37_1; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Host nucleus; Reference proteome;
KW   Virion; Virion tegument.
FT   CHAIN           1..1038
FT                   /note="Inner tegument protein"
FT                   /id="PRO_0000116050"
FT   REGION          545..1038
FT                   /note="Interaction with large tegument protein"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04043"
SQ   SEQUENCE   1038 AA;  115780 MW;  40C7A68829F0E297 CRC64;
     MEEPICYDTQ KLLDDLSNLK VQEADNERPW SPEKTEIARV KVVKFLRSTQ KIPAKHFIQI
     WEPLHSNICF VYSNTFLAEA AFTAENLPGL LFWRLDLDWT IEEPGNSLKI LTQLSSVVQD
     SETLHRLSAN KLRTSSKFGP VSIHFIITDW INMYEVALKD ATTAIESPFT HARIGMLESA
     IAALTQHKFA IIYDMPFVQE GIRVLTQYAG WLLPFNVMWN QIQNSSLTPL TRALFIICMI
     DEYLTETPVH SISELFADTV NLIKDEAFVS IEEAVTNPRT VHESRISSAL AYRDPYVFET
     SPGMLARRLR LDNGIWESNL LSLSTPGIHI EALLHLLNSD PEAETTSGSN VAEHTRGIWE
     KVQASTSPSM LISTLAESGF TRFSCKLLRR FIAHHTLAGF IHGSVVADEH ITDFQQTLGC
     LALVGGLAYQ LVETYAPTTE YVLTYTRTVN ETEKRYETLL PALGLPPGGL GQIMRRCFAP
     RPLIESIQAT RVILLNEISH AEARETTYFK QTHNQSSGAL LPQAGQSAVR EAVLTWFDLR
     MDSRWGITPP VDVGMTPPIC VDPPATGLEA VMITEALKIA YPTEYNRSSV FVEPSFVPYI
     IATSTLDALS ATIALSFDTR GIQQALSILQ WARDYGSGTV PNADGYRTKL SALITILEPF
     TRTHPPVLLP SHVSTIDSLI CELHRTVGIA VDLLPQHVRP LVPDRPSITN SVFLATLYYD
     ELYGRWTRLD KTSQALVENF TSNALVVSRY MLMLQKFFAC RFYPTPDLQA VGICNPKVER
     DEQFGVWRLN DLADAVGHIV GTIQGIRTQM RVGISSLRTI MADASSALRE CENLMTKTST
     SAIGPLFSTM ASRYARFTQD QMDILMRVDK LTTGENIPGL ANVEIFLNRW ERIATACRHA
     TAVPSAESIA TVCNELRRGL KNIQEDRVNA PTSYMSHARN LEDHKAAVSF VMDSRQQFIV
     DSGPQMGAVL TSQCNIGTWE NVNATFLHDN VKITTTVRDV ISEAPTLIIG QRWLRPDEIL
     SNVDLRLGVP GNTSGSDP