ID   ITR1_ASCSU              Reviewed;          62 AA.
AC   P19398;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Trypsin inhibitor;
DE   AltName: Full=ATI;
OS   Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6253;
RN   [1]
RP   PROTEIN SEQUENCE.
RA   Peanasky R.J., Martzen M.R., Homandberg G.A., Cash J.M., Babin D.R.,
RA   Litwiller R.D.;
RL   (In) McInnis A.J. (eds.);
RL   Paradigms for eradicating helminthic parasites, pp.349-366, Alan R. Liss,
RL   New York (1987).
RN   [2]
RP   STRUCTURE BY NMR.
RX   PubMed=2322539; DOI=10.1021/bi00453a025;
RA   Gronenborn A.M., Nilges M., Peanasky R.J., Clore G.M.;
RT   "Sequential resonance assignment and secondary structure determination of
RT   the Ascaris trypsin inhibitor, a member of a novel class of proteinase
RT   inhibitors.";
RL   Biochemistry 29:183-189(1990).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the serine protease inhibitor-like (TIL domain-
CC       containing) family. {ECO:0000305}.
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DR   PIR; S35098; S35098.
DR   PDB; 1ATA; NMR; -; A=1-62.
DR   PDB; 1ATB; NMR; -; A=1-62.
DR   PDB; 1ATD; NMR; -; A=1-62.
DR   PDB; 1ATE; NMR; -; A=1-62.
DR   PDBsum; 1ATA; -.
DR   PDBsum; 1ATB; -.
DR   PDBsum; 1ATD; -.
DR   PDBsum; 1ATE; -.
DR   AlphaFoldDB; P19398; -.
DR   BMRB; P19398; -.
DR   SMR; P19398; -.
DR   MEROPS; I08.007; -.
DR   EvolutionaryTrace; P19398; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   Pfam; PF01826; TIL; 1.
DR   SUPFAM; SSF57567; SSF57567; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Disulfide bond;
KW   Protease inhibitor; Secreted; Serine protease inhibitor.
FT   CHAIN           1..62
FT                   /note="Trypsin inhibitor"
FT                   /id="PRO_0000174331"
FT   DOMAIN          5..60
FT                   /note="TIL"
FT   DISULFID        5..38
FT   DISULFID        15..33
FT   DISULFID        18..29
FT   DISULFID        22..60
FT   DISULFID        40..54
FT   STRAND          6..9
FT                   /evidence="ECO:0007829|PDB:1ATA"
FT   STRAND          11..15
FT                   /evidence="ECO:0007829|PDB:1ATA"
FT   STRAND          36..39
FT                   /evidence="ECO:0007829|PDB:1ATA"
FT   TURN            42..45
FT                   /evidence="ECO:0007829|PDB:1ATA"
FT   STRAND          46..49
FT                   /evidence="ECO:0007829|PDB:1ATA"
FT   TURN            50..52
FT                   /evidence="ECO:0007829|PDB:1ATA"
FT   STRAND          53..57
FT                   /evidence="ECO:0007829|PDB:1ATA"
SQ   SEQUENCE   62 AA;  6798 MW;  6438D25D2F76D3E1 CRC64;
     EAEKCTKPNE QWTKCGGCEG TCAQKIVPCT RECKPPRCEC IASAGFVRDA QGNCIKFEDC
     PK