ID   ITRY1_BAURF             Reviewed;         164 AA.
AC   P84882;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Kunitz-type trypsin inhibitor BrTI;
OS   Bauhinia rufa (Orchid tree) (Pauletia rufa).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Cercidoideae; Cercideae; Bauhiniinae;
OC   Bauhinia.
OX   NCBI_TaxID=390785;
RN   [1]
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Seed;
RX   PubMed=16846639; DOI=10.1016/j.ijbiomac.2006.05.008;
RA   Nakahata A.M., Bueno N.R., Rocha H.A.O., Franco C.R.C., Chammas R.,
RA   Nakaie C.R., Jasiulionis M.G., Nader H.B., Santana L.A., Sampaio M.U.,
RA   Oliva M.L.V.;
RT   "Structural and inhibitory properties of a plant proteinase inhibitor
RT   containing the RGD motif.";
RL   Int. J. Biol. Macromol. 40:22-29(2006).
CC   -!- FUNCTION: Inhibitor of trypsin and human plasma kallikrein with a Ki of
CC       2.9 nM and 14.0 nM, respectively. Does not inhibit chymotrypsin,
CC       porcine pancreatic elastas, human neutrophil elastase, coagulation
CC       factor Xa, human thrombin, porcine pancreatic kallikrein or plasmin.
CC       {ECO:0000269|PubMed:16846639}.
CC   -!- SIMILARITY: Belongs to the leguminous Kunitz-type inhibitor family.
CC       {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P84882; -.
DR   SMR; P84882; -.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011065; Kunitz_inhibitor_STI-like_sf.
DR   InterPro; IPR002160; Prot_inh_Kunz-lg.
DR   PANTHER; PTHR33107; PTHR33107; 1.
DR   Pfam; PF00197; Kunitz_legume; 1.
DR   SMART; SM00452; STI; 1.
DR   SUPFAM; SSF50386; SSF50386; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Protease inhibitor; Serine protease inhibitor.
FT   CHAIN           1..164
FT                   /note="Kunitz-type trypsin inhibitor BrTI"
FT                   /id="PRO_0000245797"
FT   SITE            63..64
FT                   /note="Reactive bond for elastase"
FT                   /evidence="ECO:0000269|PubMed:16846639"
SQ   SEQUENCE   164 AA;  18326 MW;  0CD664F29698F9D6 CRC64;
     SVVLDTKGQP VRNAADAYYL EPVARGDGGL ALAKVGNEAE PKAVVLDPNH RPGLTVRFET
     PLRINIIKES FFLNIKFVPS SSESEVWEVR QQYPEGLAVK VTDTKSLVGP FRVEKEGEGY
     KIVYYPDRGE TGLDIGLVHR NEKYYLAVKD GEPFVFKIRK ATDE