ID   IUTA_ECOLX              Reviewed;         732 AA.
AC   P14542;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Ferric aerobactin receptor;
DE   AltName: Full=Cloacin receptor;
DE   Flags: Precursor;
GN   Name=iutA;
OS   Escherichia coli.
OG   Plasmid IncFI ColV3-K30.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=F344;
RA   Krone W.J.A., Stegehuis F., Koningstein G., van Doorn C., Roosendaal B.,
RA   de Graaf F.K., Oudega B.;
RT   "Characterization of the pColV-K30 encoded cloacin DF13/aerobactin outer
RT   membrane receptor protein of Escherichia coli; isolation and purification
RT   of the protein and analysis of its nucleotide sequence and primary
RT   structure.";
RL   FEMS Microbiol. Lett. 26:153-161(1985).
RN   [2]
RP   FUNCTION AS AN AEROBACTIN RECEPTOR, IDENTIFICATION, INDUCTION, AND
RP   SUBCELLULAR LOCATION.
RX   PubMed=7042696; DOI=10.1128/jb.150.3.1472-1475.1982;
RA   Bindereif A., Braun V., Hantke K.;
RT   "The cloacin receptor of ColV-bearing Escherichia coli is part of the Fe3+-
RT   aerobactin transport system.";
RL   J. Bacteriol. 150:1472-1475(1982).
CC   -!- FUNCTION: Receptor for cloacin DF13/aerobactin.
CC       {ECO:0000269|PubMed:7042696}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:7042696}.
CC   -!- INDUCTION: Under iron starvation. {ECO:0000269|PubMed:7042696}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA29298.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; X05874; CAA29297.1; -; Genomic_DNA.
DR   EMBL; X05874; CAA29298.1; ALT_INIT; Genomic_DNA.
DR   PIR; S01042; S01042.
DR   AlphaFoldDB; P14542; -.
DR   SMR; P14542; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0019271; P:aerobactin transport; IMP:UniProtKB.
DR   GO; GO:0055072; P:iron ion homeostasis; IMP:UniProtKB.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR010916; TonB_box_CS.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   InterPro; IPR010105; TonB_sidphr_rcpt.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01783; TonB-siderophor; 1.
DR   PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Ion transport; Iron; Iron transport; Membrane;
KW   Plasmid; Receptor; Signal; TonB box; Transport.
FT   SIGNAL          1..25
FT   CHAIN           26..732
FT                   /note="Ferric aerobactin receptor"
FT                   /id="PRO_0000034767"
FT   MOTIF           31..38
FT                   /note="TonB box"
FT   MOTIF           715..732
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   732 AA;  81014 MW;  0C23879C0B27AE2B CRC64;
     MMISKKYTLW ALNPLLLTMM APAVAQQTDD ETFVVSANRS NRTVAEMAQT TWVIENAELE
     QQIQGGKELK DALAQLIPGL DVSSRSRTNY GMNVRGRPLV VLVDGVRLNS SRTDSRQLDS
     IDPFNMHHIE VIFGATSLYG GGSTGGLINI VTKKGQPETM MEFEAGTKSG FSSSKDHDER
     IAGAVSGGNE HISGRLSVAY QKFGGWFDGN GDATLLDNTQ TGLQYSDRLD IMGTGTLNID
     ESRQLQLITQ YYKSQGDDDY GLNLGKGFSA IRGTSTPFVS NGLNSDRIPG TDGHLISLQY
     SDSAFLGQEL VGQVYYRDES LRFYPFPTVN ANKQVTAFSS SQQDTDQYGM KLTLNSKPMD
     GWQITWGLDA DHERFTSNQM FFDLAQASAS GGLNNKKIYT TGRYPSYDIT NLAAFLQSGY
     DINNLFTLNG GVRYQYTENK IDDFIGYAQQ RQIGAGKATS ADAFWRLSRL RHFLFNAGLL
     MHITEPQQAW LNFSQGLELP DPGKYYGRGI YGAAVNGHLP LTKSVNVSDS KLEGVKVDSY
     ELGWRFTGNN LRTQIAAYYS ISDKSVVANK DLTISVVDDK RRIYGVEGAV DYLIPDTDWS
     TGVNFNVLKT ESKVNGTWQK YDVKTASPSK ATAYIGWAPD PWSLRVQSTT SFDVSDAQGY
     KVDGYTTVDL LGSYQLPVGT LSFSIENLFD RDYTTVWGQR APLYYSPGYG PASLYDYKGR
     GRTFGLNYSV LF